Evidence map›Paper›PMID 37958904›Full record

ReviewInternational journal of molecular sciences2023

Modeling Liver Development and Disease in a Dish.

Waqas Iqbal, Yaru Wang, Pingnan Sun, Xiaoling Zhou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Development of ovine hepatic organoids: a powerfulFrontiers in veterinary science · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Waqas IqbalStem Cell Research Center, Shantou University Medical College, Shantou 515041, China.
Yaru WangStem Cell Research Center, Shantou University Medical College, Shantou 515041, China.
Pingnan SunStem Cell Research Center, Shantou University Medical College, Shantou 515041, China.ORCID 0000-0002-3325-8062
Xiaoling ZhouStem Cell Research Center, Shantou University Medical College, Shantou 515041, China.ORCID 0000-0001-5721-944X
Shantou University · CN

Funding

National Natural Science Foundation of China 81950410640; 81870432
6 · The paper itself

Abstract

Historically, biological research has relied primarily on animal models. While this led to the understanding of numerous human biological processes, inherent species-specific differences make it difficult to answer certain liver-related developmental and disease-specific questions. The advent of 3D organoid models that are either derived from pluripotent stem cells or generated from healthy or diseased tissue-derived stem cells have made it possible to recapitulate the biological aspects of human organs. Organoid technology has been instrumental in understanding the disease mechanism and complements animal models. This review underscores the advances in organoid technology and specifically how liver organoids are used to better understand human-specific biological processes in development and disease. We also discuss advances made in the application of organoid models in drug screening and personalized medicine.

Indexed as

Pluripotent Stem CellsAnimalsHumansLiverOrganoidshuman pluripotent stem cellliver developmentmetabolic liver diseaseorganoidsorgan-on-chipprimary liver cancerregenerative medicineviral infection

Identifiers

PMID37958904
PMCPMC10650907
OpenAlexW4388298113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.