Evidence map›Paper›PMID 37958828›Full record

ArticleInternational journal of molecular sciences2023

Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats.

Hala A Hafez, Ali M Atoom, Rana H M Khafaga, Sara A Shaker, Maher A Kamel, Nagwa M Assem, Shimaa A Mahmoud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hala A HafezDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.ORCID 0000-0003-3266-6897
Ali M AtoomDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19111, Jordan.ORCID 0000-0001-9742-4253
Rana H M KhafagaDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.
Sara A ShakerDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.ORCID 0000-0002-7251-8648
Maher A KamelDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.ORCID 0000-0002-6791-9850
Nagwa M AssemDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.
Shimaa A MahmoudDepartment of Biochemistry, Medical Research Institute, Alexandria University, Alexandria 21561, Egypt.
Alexandria University · EGAl-Ahliyya Amman University · JO

Funding

Science and Technology Development Fund 33350
6 · The paper itself

Abstract

(1) Background: Hepatitis C virus (HCV) infection is endemic in Egypt, with the highest prevalence rate worldwide. Sofosbuvir (SOF) is a nucleos(t)ide analog that specifically inhibits HCV replication. This study aimed to explore the possible effects of the therapeutic dose of SOF on the mitochondrial biogenesis and functions of the liver, muscle, and ovarian tissues of young normal female rats. (2) Methods: This study was conducted on 20 female Wistar rats, classified into two groups, the control group and the exposed group; the latter was orally supplemented with 4 mg/kg/day of SOF for 3 months. (3) Results: The exposure to SOF impairs mitochondrial biogenesis via mitochondrial DNA copy number decline and suppressed mitochondrial biogenesis-regulated parameters at mRNA and protein levels. Also, SOF suppresses the DNA polymerase γ (POLG) expression, citrate synthase activity, and mitochondrial NADH dehydrogenase subunit-5 (ND5) content, which impairs mitochondrial functions. SOF increased lipid peroxidation and oxidative DNA damage markers and decreased tissue expression of nuclear factor erythroid 2-related factor 2 (Nfe2l2). (4) Conclusions: The present findings demonstrate the adverse effects of SOF on mitochondrial biogenesis and function in different tissues of young female rats, which mostly appeared in ovarian tissues.

Indexed as

Hepatitis CHepatitis C, ChronicAnimalsAntiviral AgentsDrug Therapy, CombinationFemaleGenotypeHepacivirusOrganelle BiogenesisRatsRats, WistarSofosbuvirTreatment OutcomeAntiviral AgentsSofosbuvirDNA polymerase γhepatitis Cmitochondrial DNASofosbuvir

Identifiers

PMID37958828
PMCPMC10647297
OpenAlexW4388048738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.