Molecular Mechanisms for Changing Brain Connectivity in Mice and Humans.

Pascale Voelker, Aldis P Weible, Cristopher M Niell, Mary K Rothbart, Michael I Posner

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 50% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Pascale VoelkerDepartment of Psychology, University of Oregon, Eugene, OR 97403, USA.

Aldis P WeibleInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.

Cristopher M NiellInstitute of Neuroscience, University of Oregon, Eugene, OR 97403, USA.

Mary K RothbartDepartment of Psychology, University of Oregon, Eugene, OR 97403, USA.

Michael I PosnerDepartment of Psychology, University of Oregon, Eugene, OR 97403, USA.ORCID 0000-0002-7060-987X

University of Oregon · US

Funding

Office of Naval Research N00014-2 22-1-2118

6 · The paper itself

Abstract

The goal of this study was to examine commonalities in the molecular basis of learning in mice and humans. In previous work we have demonstrated that the anterior cingulate cortex (ACC) and hippocampus (HC) are involved in learning a two-choice visuospatial discrimination task. Here, we began by looking for candidate genes upregulated in mouse ACC and HC with learning. We then determined which of these were also upregulated in mouse blood. Finally, we used RT-PCR to compare candidate gene expression in mouse blood with that from humans following one of two forms of learning: a working memory task (network training) or meditation (a generalized training shown to change many networks). Two genes were upregulated in mice following learning: caspase recruitment domain-containing protein 6 (

Indexed as

CARD Signaling Adaptor ProteinsSignal TransductionAnimalsBrainHumansLearningMiceNF-kappa BCard6 protein, mouseCARD Signaling Adaptor ProteinsNF-kappa Banterior cingulate cortexCard6hippocampusmyelinnetwork trainingNF-κBnodal distancestate trainingtheta rhythm

Identifiers

PMID37958822

DOI10.3390/ijms242115840

PMCPMC10648558

OpenAlexW4388042189

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.