Evidence map›Paper›PMID 37958785›Full record

ArticleInternational journal of molecular sciences2023

TLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response.

Cinzia Zucchini, Carmela Serpe, Paola De Sanctis, Alessandro Ghezzo, Paola Visconti, Annio Posar, Federica Facchin, Marina Marini, Provvidenza Maria Abruzzo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. NCOA7 promotes OSCC progression by inhibiting ROS-regulated ferroptosis.Cellular and molecular life sciences : CMLS · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Cinzia ZucchiniDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Carmela SerpeDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Paola De SanctisDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.
Alessandro GhezzoGrioni Center-Danelli Foundation, Largo Stefano ed Angela Danelli 1, 26900 Lodi, Italy.
Paola ViscontiIRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Via Altura 3, 40139 Bologna, Italy.
Annio PosarIRCCS Istituto delle Scienze Neurologiche di Bologna, UOSI Disturbi dello Spettro Autistico, Via Altura 3, 40139 Bologna, Italy.ORCID 0000-0002-5024-4578
Federica FacchinDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0002-7886-3186
Marina MariniDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0003-1932-7380
Provvidenza Maria AbruzzoDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy.ORCID 0000-0001-5242-9448
University of Bologna · ITIstituto delle Scienze Neurologiche di Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress (OS) plays a key role in autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by deficits in social communication, restricted interests, and repetitive behaviors. Recent evidence suggests that the TLDc [Tre2/Bub2/Cdc16 (TBC), lysin motif (LysM), domain catalytic] domain is a highly conserved motif present in proteins that are important players in the OS response and in neuroprotection. Human proteins sharing the TLDc domain include OXR1, TLDC1, NCOA7, TBC1D24, and C20ORF118. This study was aimed at understanding whether TLDc domain-containing mRNAs together with specific microRNAs (200b-3p and 32-5p) and long noncoding RNAs (TUG1), known to target TLDc proteins, contributed to regulate the OS response in ASD. Data showed a significant increase in the levels of

Indexed as

Autism Spectrum DisorderChildGTPase-Activating ProteinsHumansLeukocytes, MononuclearOxidation-ReductionOxidative StressProteinsGTPase-Activating ProteinsProteinsTBC1D24 protein, humanautism spectrum disorderinflammationlncRNAsmiRNAsNRF2oxidative stressOXR1TLDC1TLDc domain-containing proteinsTUG1

Identifiers

PMID37958785
PMCPMC10647648
OpenAlexW4388070623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.