Evidence map›Paper›PMID 37958748›Full record

ArticleInternational journal of molecular sciences2023

The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier Fly

Atsuyoshi Nakagawa, Takuma Sakamoto, Michael R Kanost, Hiroko Tabunoki

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Impact ofInsects · 2025
    Article
  5. Article
  6. Investigating the Microbial Dynamics ofFoods (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Proteomic Analysis ofAntibiotics (Basel, Switzerland) · 2024
    Article
  9. Article
  10. Evaluation of the Microbial Quality ofFoods (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Atsuyoshi NakagawaFuture Tech Laboratory, Corporate Research & Development, UBE Corporation, 8-1 Goi-Minamikaigan, Chiba 290-0045, Japan.
Takuma SakamotoDepartment of Science of Biological Production, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-Cho, Tokyo 183-8509, Japan.
Michael R KanostDepartment of Biochemistry and Molecular Biophysics, Kansas State University, 141 Chalmers Hall, Manhattan, KS 66506-3702, USA.ORCID 0000-0002-6827-0061
Hiroko TabunokiCooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.ORCID 0000-0003-1823-9952
Tokyo University of Agriculture and Technology · JPKansas State University · USUbe (Japan) · JP

Funding

Function of hemolymph plasma proteins in insect immune responses (Equipment Supplement)R35GM141859 · NIGMS · KANSAS STATE UNIVERSITY · PI KANOST, MICHAEL R · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM141859NIH HHS R35 GM141859
6 · The paper itself

Abstract

(1) The global population is projected to reach a staggering 9.8 billion people by the year 2050, leading to major concerns about food security. The necessity to increase livestock production is inevitable. The black soldier fly (BSF) is known for its ability to consume a wide range of organic waste, and BSF larvae have already been used as a partial substitute for fishmeal. In contrast, the use of antibiotics in livestock feed for growth promotion and prophylaxis poses a severe threat to global health owing to antimicrobial resistance. Insect antimicrobial peptides (AMPs) have shown the potential to rapidly disrupt target bacterial membranes, making bacterial resistance to AMPs a less likely concern. (2) In this study, we explored various methods for stimulating AMP synthesis in BSF larvae and found that thermal injury effectively induced the production of various AMP types. Additionally, we investigated the activation of innate immune response pathways that lead to AMP production following thermal injury. (3) Interestingly, thermal injury treatment, although not involving bacteria, exhibited a similar response to that observed following Gram-positive bacterial infection in eliciting the expression of AMP genes. (4) Our findings offer support for the industrial use of BSF to enhance livestock production and promote environmental health.

Indexed as

Antimicrobial PeptidesDipteraAnimalsBacteriaHumansLarvaLivestockAntimicrobial Peptidesantimicrobial peptides (AMPs)black soldier flyGram-positive bacteriathermal injury

Identifiers

PMID37958748
PMCPMC10647447
OpenAlexW4388020275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.