Evidence map›Paper›PMID 37958742›Full record

ArticleInternational journal of molecular sciences2023

Tuning the Envelope Structure of Enzyme Nanoreactors for In Vivo Detoxification of Organophosphates.

Tatiana Pashirova, Zukhra Shaihutdinova, Dmitry Tatarinov, Milana Mansurova, Renata Kazakova, Andrei Bogdanov, Eric Chabrière, Pauline Jacquet, David Daudé, Almaz A Akhunzianov and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Tatiana PashirovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, 420088 Kazan, Russia.ORCID 0000-0002-2001-1570
Zukhra ShaihutdinovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, 420088 Kazan, Russia.ORCID 0009-0008-5713-4137
Dmitry TatarinovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, 420088 Kazan, Russia.
Milana MansurovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Renata KazakovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-2109-569X
Andrei BogdanovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, 420088 Kazan, Russia.
Eric ChabrièreGene&GreenTK, 19-21 Boulevard Jean Moulin, 13005 Marseille, France.
Pauline JacquetGene&GreenTK, 19-21 Boulevard Jean Moulin, 13005 Marseille, France.
David DaudéGene&GreenTK, 19-21 Boulevard Jean Moulin, 13005 Marseille, France.ORCID 0000-0002-0995-5554
Almaz A AkhunzianovInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Regina R MiftakhovaInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-6686-1968
Patrick MassonInstitute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.ORCID 0000-0002-7837-3662
Kazan Federal University · RUA.E. Arbuzov Institute of Organic and Physical Chemistry · RUGene and GreenTK (France) · FRAix-Marseille Université · FR

Funding

Russian Science Foundation 20-14-00155
6 · The paper itself

Abstract

Encapsulated phosphotriesterase nanoreactors show their efficacy in the prophylaxis and post-exposure treatment of poisoning by paraoxon. A new enzyme nanoreactor (E-nRs) containing an evolved multiple mutant (L72C/Y97F/Y99F/W263V/I280T) of

Indexed as

OrganophosphatesPhosphoric Triester HydrolasesAnimalsNanotechnologyParaoxonOrganophosphatesParaoxonPhosphoric Triester Hydrolasesenzyme nanoreactorimmune responseorganophosphate poisoningpharmacokineticsphosphotriesterasepolymersomespost-exposure treatmentprophylaxis

Identifiers

PMID37958742
PMCPMC10649860
OpenAlexW4388019918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.