Evidence map›Paper›PMID 37958741›Full record

ArticleInternational journal of molecular sciences2023

Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom.

Tong Qin, Bei Hu, Qianwei Zhao, Yali Wang, Shaoxin Wang, Danyan Luo, Jiazhen Lyu, Yiqing Chen, Jianhua Gan, Zhen Huang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Duplicate entries in the Protein Data Bank: how to detect and handle them.Acta crystallographica. Section D, Structural biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tong QinKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
Bei HuKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.ORCID 0000-0002-9925-0661
Qianwei ZhaoKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
Yali WangCollege of Bioengineering, Sichuan University of Science and Engineering, Yibin 644000, China.
Shaoxin WangKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
Danyan LuoSeNA Research Institute and Szostak-CDHT Large Nucleic Acid Institute, Chengdu 618000, China.
Jiazhen LyuKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
Yiqing ChenShanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Jianhua GanShanghai Public Health Clinical Center, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China.
Zhen HuangKey Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China.
Sichuan University · CNShanghai Public Health Clinical Center · CNSichuan University of Science and Engineering · CN

Funding

he Natural Science Foundation - Youth Science Foundation Project 22107079National Natural Science Foundation of China 22077089, 32171197Open Research Fund of State Key Laboratory of Southwest Chinese Traditional Medicine Re-sources SKLTCM202202Science & Technology Department of Sichuan Province-Key research and development project 2022YFSY0013, 2023NSFSC1107 and 2021YJ0319the China Postdoctoral Science Foundation 2020M673205the National Key Research and Development Program 2022YFC2303700
6 · The paper itself

Abstract

DNA synthesis catalyzed by DNA polymerase is essential for all life forms, and phosphodiester bond formation with phosphorus center inversion is a key step in this process. Herein, by using a single-selenium-atom-modified dNTP probe, we report a novel strategy to visualize the reaction stereochemistry and catalysis. We capture the before- and after-reaction states and provide explicit evidence of the center inversion and in-line attacking S

Indexed as

SeleniumCatalysisDNADNA-Directed DNA PolymeraseIonsKineticsMetalsDNADNA-Directed DNA PolymeraseIonsMetalsSeleniumconfiguration inversionmetal ionsphosphodiester bond formationpolymerasesingle selenium atom

Identifiers

PMID37958741
PMCPMC10647396
OpenAlexW4388104098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.