Evidence map›Paper›PMID 37958631›Full record

ArticleInternational journal of molecular sciences2023

Differential Influences of Endogenous and Exogenous Sensory Neuropeptides on the ATP Metabolism by Soluble Ectonucleotidases in the Murine Bladder Lamina Propria.

Alejandro Gutierrez Cruz, Mafalda S L Aresta Branco, Mahsa Borhani Peikani, Violeta N Mutafova-Yambolieva

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alejandro Gutierrez CruzDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV 89557, USA.ORCID 0000-0002-4240-2740
Mafalda S L Aresta BrancoDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV 89557, USA.ORCID 0000-0001-5210-9137
Mahsa Borhani PeikaniDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV 89557, USA.
Violeta N Mutafova-YambolievaDepartment of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV 89557, USA.ORCID 0000-0003-2519-3323
University of Nevada, Reno · US

Funding

Urothelial Purinergic Signaling During Bladder FillingR01DK119482 · NIDDK · UNIVERSITY OF NEVADA RENO · PI Violeta N. Mutafova-Yambolieva · 2020 to 2026
$3.3M
NIDDK NIH HHS R01 DK119482NIH HHS DK119482
6 · The paper itself

Abstract

Bladder urothelium and suburothelium/lamina propria (LP) have prominent sensory and transducer functions with the active participation of afferent neurons and urothelium-derived purine mediators such as adenosine 5'-triphosphate (ATP), adenosine 5'-diphosphate (ADP), and adenosine (ADO). Effective concentrations of purines at receptor targets depend significantly on the extracellular degradation of ATP by ectonucleotidases (ENTDs). We recently reported the regulated release of soluble ENTDs (s-ENTDs) in the LP and the consequent degradation of ATP to ADP, AMP, and ADO. Afferent neurons in the LP can be activated by urothelial ATP and release peptides and other transmitters that can alter the activity of cells in their vicinity. Using a murine decentralized ex vivo detrusor-free bladder model, 1,N

Indexed as

Pituitary Adenylate Cyclase-Activating PolypeptideUrinary BladderAdenosineAdenosine TriphosphateAnimalsCalcitonin Gene-Related PeptideMiceMucous MembraneNeurokinin APurinesAdenosineAdenosine TriphosphateCalcitonin Gene-Related PeptideNeurokinin APituitary Adenylate Cyclase-Activating PolypeptidePurinesATPbladderCGRPectonucleotidasesneurokinin AneuropeptidesPACAPpurinergic signalingsubstance Purothelium

Identifiers

PMID37958631
PMCPMC10647406
OpenAlexW4387973478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.