Evidence map›Paper›PMID 37958578›Full record

ArticleInternational journal of molecular sciences2023

Genetic and Phenotypic Analysis of Phage-Resistant Mutant Fitness Triggered by Phage-Host Interactions.

Yanze Mi, Yile He, Jinhui Mi, Yunfei Huang, Huahao Fan, Lihua Song, Xiaoping An, Shan Xu, Mengzhe Li, Yigang Tong

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Engineering broad-spectrum phage-resistantApplied and environmental microbiology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Synergistic efficacy of phage Henu10 with antibiotics againstFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yanze MiCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Yile HeCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Jinhui MiCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Yunfei HuangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Huahao FanCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0001-5007-2158
Lihua SongCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Xiaoping AnCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Shan XuCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Mengzhe LiCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Yigang TongCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.ORCID 0000-0002-8503-8045
Beijing University of Chemical Technology · CN

Funding

China Postdoctoral Science Foundation 2022M710330Fundamental Research Funds for Central Universities No. BUCTRC201917, BUCTZY2022Funds for First-class Discipline Construction No. XK1805Key Project of Beijing University of Chemical Technology No.XK1803-06Key Research and Development Program of Hebei Province 22322908DMilitary Biosecurity Research Program No.20SWAQX27National Key Research and Development Program of China No. 2021YFA0911200National Natural Science Foundation of China 32001834
6 · The paper itself

Abstract

The emergence of phage-resistant bacterial strains is one of the biggest challenges for phage therapy. However, the emerging phage-resistant bacteria are often accompanied by adaptive trade-offs, which supports a therapeutic strategy called "phage steering". The key to phage steering is to guide the bacterial population toward an evolutionary direction that is favorable for treatment. Thus, it is important to systematically investigate the impacts of phages targeting different bacterial receptors on the fitness of the bacterial population. Herein, we employed 20 different phages to impose strong evolutionary pressure on the host

Indexed as

BacteriophagesAnti-Bacterial AgentsBiological EvolutionLipopolysaccharidesPseudomonas aeruginosaVirulenceAnti-Bacterial AgentsLipopolysaccharidesfitness costphage resistancephage steeringphage therapyreceptor-related mutants

Identifiers

PMID37958578
PMCPMC10648725
OpenAlexW4388201969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.