Evidence map›Paper›PMID 37958573›Full record

ArticleInternational journal of molecular sciences2023

Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study.

Inmaculada Rodriguez-Martin, Gonzalo Villanueva-Martin, Alfredo Guillen-Del-Castillo, Norberto Ortego-Centeno, José L Callejas, Carmen P Simeón-Aznar, Javier Martin, Marialbert Acosta-Herrera

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Inmaculada Rodriguez-MartinInstitute of Parasitology and Biomedicine López-Neyra, CSIC, 18016 Granada, Spain.ORCID 0000-0001-5413-1581
Gonzalo Villanueva-MartinInstitute of Parasitology and Biomedicine López-Neyra, CSIC, 18016 Granada, Spain.ORCID 0000-0002-3585-4319
Alfredo Guillen-Del-CastilloDepartment of Internal Medicine, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0003-0626-507X
Norberto Ortego-CentenoSystemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, 18012 Granada, Spain.
José L CallejasSystemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, 18012 Granada, Spain.
Carmen P Simeón-AznarDepartment of Internal Medicine, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0003-3390-9029
Javier MartinInstitute of Parasitology and Biomedicine López-Neyra, CSIC, 18016 Granada, Spain.ORCID 0000-0002-2202-0622
Marialbert Acosta-HerreraInstitute of Parasitology and Biomedicine López-Neyra, CSIC, 18016 Granada, Spain.ORCID 0000-0002-9868-6535

Funding

Instituto de Salud Carlos III CP21/00132Instituto de Salud Carlos III RD21/0002/0039Ministerio de Ciencia e Innovación PRE2019-087586Ministerio de Universidades FPU21/02746
6 · The paper itself

Abstract

Although previous studies have suggested a relationship between telomere shortening and systemic sclerosis (SSc), the association between these two traits remains poorly understood. The objective of this study was to assess the causal relationship between telomere length in leukocytes (LTL) and SSc using the two-sample Mendelian randomization approach, with the genome-wide association study data for both LTL and SSc. The results of inverse-variance weighted regression (OR = 0.716 [95% CI 0.528-0.970],

Indexed as

Genome-Wide Association StudyScleroderma, SystemicHumansLeukocytesMendelian Randomization AnalysisPolymorphism, Single NucleotideTelomeremendelian randomizationsystemic sclerosistelomere length

Identifiers

PMID37958573
PMCPMC10648506

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.