Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in

Jack Cheng, Bor-Tsang Wu, Hsin-Ping Liu, Wei-Yong Lin

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.8field-weighted citation impact, top 25% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

International journal of molecular sciences · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jack ChengGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

Bor-Tsang WuDepartment of Senior Citizen Service Management, National Taichung University of Science and Technology, Taichung 40343, Taiwan.

Hsin-Ping LiuGraduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-2569-3072

Wei-Yong LinGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-8443-6180

China Medical University · TWNational Taichung University of Science and Technology · TW

Funding

China Medical University Hospital Taiwan DMR-112-125China Medical University Taiwan CMU110-MF-92China Medical University Taiwan CMU111-MF-50National Science and Technology Council of Taiwan MOST 111-2314-B-039-017-MY3National Science and Technology Council of Taiwan MOST 111-2320-B-039-032

6 · The paper itself

Abstract

LRRK2 mutations are the leading cause of familial Parkinson's disease (PD) and are a significant risk factor for idiopathic PD cases. However, the molecular mechanisms underlying the degeneration of dopaminergic (DA) neurons in LRRK2 PD patients remain unclear. To determine the translatomic impact of LRRK2 expression in DA neurons, we employed gene set enrichment analysis (GSEA) to analyze a translating ribosome affinity purification (TRAP) RNA-seq dataset from a DA-neuron-specific-expressing

Indexed as

Dopaminergic NeuronsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Parkinson DiseaseAnimalsDrosophilaDrosophila ProteinsHumansMutationNerve DegenerationProtein Serine-Threonine KinasesTyrosineDrosophila ProteinsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK protein, DrosophilaProtein Serine-Threonine KinasesTyrosinedopaminergic neuronLRRK2Parkinson’s diseasetyrosine metabolism

Identifiers

PMID37958569

DOI10.3390/ijms242115587

PMCPMC10650192

OpenAlexW4387936898

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.