Evidence map›Paper›PMID 37958567›Full record

ArticleInternational journal of molecular sciences2023

Proteomic Analyses Discern the Developmental Inclusion of Albumin in Pig Enamel: A New Model for Human Enamel Hypomineralization.

Ana Gil-Bona, Hakan Karaaslan, Baptiste Depalle, Rosalyn Sulyanto, Felicitas B Bidlack

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Posteruptive Loss of Proteins in Porcine Enamel.Journal of dental research · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ana Gil-BonaThe Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
Hakan KaraaslanThe Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.ORCID 0000-0003-4766-769X
Baptiste DepalleThe Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.ORCID 0000-0002-5789-0636
Rosalyn SulyantoDepartment of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA.
Felicitas B BidlackThe Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.ORCID 0000-0001-8105-223X
Harvard University · USBoston Children's Hospital · US

Funding

Enamel matrix 3D organization and maturation stage ion flowR01DE025865 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BIDLACK, FELICITAS B · 2016 to 2020
$2.4M
Forsyth Training in Oral Health ResearchR90DE027638 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI THOMAS Elliott VAN DYKE · 2017 to 2026
$1.0M
Saliva-mediated Mechanisms of Post-Eruptive Enamel MineralizationR21DE026874 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI BIDLACK, FELICITAS B · 2018 to 2019
$547k
NIDCR NIH HHS R01 DE025865NIDCR NIH HHS R21 DE026874NIDCR NIH HHS R90 DE027638
6 · The paper itself

Abstract

Excess albumin in enamel is a characteristic of the prevalent developmental dental defect known as chalky teeth or molar hypomineralization (MH). This study uses proteomic analyses of pig teeth to discern between developmental origin and post-eruptive contamination and to assess the similarity to hypomineralized human enamel. Here, the objective is to address the urgent need for an animal model to uncover the etiology of MH and to improve treatment. Porcine enamel is chalky and soft at eruption; yet, it hardens quickly to form a hard surface and then resembles human teeth with demarcated enamel opacities. Proteomic analyses of enamel from erupted teeth, serum, and saliva from pigs aged 4 (

Indexed as

alpha-FetoproteinsDental EnamelProteomicsAlbuminsAnimalsDental Enamel HypomineralizationHumansIncisorPeptidesPrevalenceSwineTandem Mass SpectrometryAlbuminsalpha-FetoproteinsPeptideschalky teethdemarcated enamel opacitydental developmentdevelopmental dental defectenamel proteomicsfetal albuminmineral maturationmolar hypomineralizationmolar incisor hypo-mineralizationporcine animal modelpost-eruptive enamel hardeningprotein time stamptooth enamel proteins

Identifiers

PMID37958567
PMCPMC10650821
OpenAlexW4387936981

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.