Evidence map›Paper›PMID 37958526›Full record

ArticleInternational journal of molecular sciences2023

Comparative Effects of Intra-Articular versus Intravenous Mesenchymal Stromal Cells Therapy in a Rat Model of Osteoarthritis by Destabilization of Medial Meniscus.

Felipe Bruno Dias de Oliveira, Eliane Antonioli, Olívia Furiama Metropolo Dias, Jean Gabriel de Souza, Sudha Agarwal, Ana Marisa Chudzinski-Tavassi, Mario Ferretti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Felipe Bruno Dias de OliveiraHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Eliane AntonioliHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Olívia Furiama Metropolo DiasHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0003-0168-9367
Jean Gabriel de SouzaDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48202, USA.
Sudha AgarwalDivision of Rheumatology and Immunology, The Ohio State University College of Medicine, Columbus, OH 43210, USA.
Ana Marisa Chudzinski-TavassiCENTD Centre of Excellence in New Target Discovery, Butantan Institute, São Paulo 05503-900, Brazil.
Mario FerrettiHospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Hospital Israelita Albert Einstein · BRInstituto Butantan · BRThe Ohio State University · USWayne State University · US

Funding

São Paulo Research Foundation 2015/14444-3São Paulo Research Foundation 2015/16606-0São Paulo Research Foundation 2018/23457-0
6 · The paper itself

Abstract

Transplanted mesenchymal stromal cells (MSCs) exhibit a robust anti-inflammatory and homing capacity in response to high inflammatory signals, as observed in studies focused on rheumatic diseases that target articular cartilage (AC) health. However, AC degradation in osteoarthritis (OA) does not necessarily coincide with a highly inflammatory joint profile. Often, by the time patients seek medical attention, they already have damaged AC. In this study, we examined the therapeutic potential of a single bone marrow MSC transplant (2 × 10

Indexed as

Cartilage, ArticularMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteoarthritisAnimalsAnti-Inflammatory AgentsFemaleHumansInjections, Intra-ArticularMenisci, TibialRatsAnti-Inflammatory Agentsinflammationintra-articularintravenousmesenchymal stem cellmesenchymal stromal cellosteoarthritis

Identifiers

PMID37958526
PMCPMC10649289
OpenAlexW4387903003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.