Evidence map›Paper›PMID 37958495›Full record

ArticleInternational journal of molecular sciences2023

Evaluation of an Image-Derived Input Function for Kinetic Modeling of Nicotinic Acetylcholine Receptor-Binding PET Ligands in Mice.

Matthew Zammit, Chien-Min Kao, Hannah J Zhang, Hsiu-Ming Tsai, Nathanial Holderman, Samuel Mitchell, Eve Tanios, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Matthew ZammitDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Chien-Min KaoDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8785-5225
Hannah J ZhangDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Hsiu-Ming TsaiDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Nathanial HoldermanDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Samuel MitchellDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Eve TaniosDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Mohammed BhuiyanDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-1116-0280
Richard FreifelderDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
Anna KucharskiDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.
William N GreenDepartment of Neurobiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-2167-1391
Jogeshwar MukherjeeDepartment of Radiological Sciences, University of California, Irvine, CA 92697, USA.
Chin-Tu ChenDepartment of Radiology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-2508-8726
University of Chicago · USFermi National Accelerator Laboratory · USMarine Biological Laboratory · USUniversity of California, Irvine · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
PET imaging of a4b2 nicotinic receptor upregulation and smoking cessationR01DA044760 · NIDA · UNIVERSITY OF CHICAGO · PI CHEN, CHIN-TU, GREEN, WILLIAM · 2017 to 2021
$3.8M
Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
Integrating Preclinical and Translational Imaging Resources for Animal ResearchS10OD025265 · OD · UNIVERSITY OF CHICAGO · PI CHEN, CHIN-TU · 2018 to 2018
$319k
NCI NIH HHS P30 CA014599NIA NIH HHS RF1 AG029479NIDA NIH HHS R01 DA044760NIDA NIH HHS T32 DA043469NIH HHS R01 DA044760NIH HHS RF1 AG029479NIH HHS S10 OD025265NIH HHS T32 DA043469
6 · The paper itself

Abstract

Positron emission tomography (PET) radioligands that bind with high-affinity to α4β2-type nicotinic receptors (α4β2Rs) allow for in vivo investigations of the mechanisms underlying nicotine addiction and smoking cessation. Here, we investigate the use of an image-derived arterial input function and the cerebellum for kinetic analysis of radioligand binding in mice. Two radioligands were explored: 2-[

Indexed as

Receptors, NicotinicTobacco Use DisorderAnimalsBrainKineticsLigandsMiceNicotinePositron-Emission TomographyLigandsNicotineReceptors, Nicotinic2-FA85380addictionkinetic modelingnicotineNifenePET

Identifiers

PMID37958495
PMCPMC10650787
OpenAlexW4387907428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.