Evidence map›Paper›PMID 37958458›Full record

ArticleCancers2023

Plasmacytoid Dendritic Cell, Slan

Francesca Pettinella, Chiara Lattanzi, Marta Donini, Elena Caveggion, Olivia Marini, Giulia Iannoto, Sara Costa, Elena Zenaro, Tiago Moderno Fortunato, Sara Gasperini and 14 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 1 country.

Francesca PettinellaGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0002-7940-589X
Chiara LattanziGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0009-0008-8988-8187
Marta DoniniGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-3101-0183
Elena CaveggionGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Olivia MariniGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Giulia IannotoGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Sara CostaGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Elena ZenaroGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0003-3928-6272
Tiago Moderno FortunatoGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Sara GasperiniGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Matteo GianiGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0009-0001-6488-4146
Lorenzo BelluominiSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.ORCID 0000-0003-1981-5499
Marco SpositoSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.ORCID 0009-0004-6749-3214
Jessica InsoldaSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.
Ilaria Mariangela ScaglioneSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.
Michele MilellaSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.
Annalisa AdamoImmunology Section, Department of Medicine, University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.
Ornella PoffeImmunology Section, Department of Medicine, University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.
Vincenzo BronteVeneto Institute of Oncology-Istituto di Ricovero e Cura a Carattere Scientifico (IOV-IRCCS), 35128 Padova, Italy.ORCID 0000-0002-3741-5141
Stefano DusiGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.ORCID 0000-0001-9753-5076
Marco A CassatellaGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
Stefano UgelImmunology Section, Department of Medicine, University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.
Sara PilottoSection of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona and University and Hospital Trust (AOUI) of Verona, 37134 Verona, Italy.ORCID 0000-0003-2229-4874
Patrizia ScapiniGeneral Pathology Section, Department of Medicine, University of Verona, 37134 Verona, Italy.
University of Verona · ITIstituto Oncologico Veneto · IT

Funding

Fondazione CARIVERONA (8974/2017)Italian Association for Cancer Research IG20339 and IG27613University of Verona RBVR17NCNC
6 · The paper itself

Abstract

The advent of immune checkpoint inhibitors (ICIs), for instance, programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) blockers, has greatly improved the outcome of patients affected by non-small cell lung cancer (NSCLC). However, most NSCLC patients either do not respond to ICI monotherapy or develop resistance to it after an initial response. Therefore, the identification of biomarkers for predicting the response of patients to ICI monotherapy represents an urgent issue. Great efforts are currently dedicated toward identifying blood-based biomarkers to predict responses to ICI monotherapy. In this study, more commonly utilized blood-based biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and the lung immune prognostic index (LIPI) score, as well as the frequency/number and activation status of various types of circulating innate immune cell populations, were evaluated in NSCLC patients at baseline before therapy initiation. The data indicated that, among all the parameters tested, low plasmacytoid dendritic cell (pDC), slan

Indexed as

blood biomarkersimmune checkpoint inhibitorsinnate immune cellsnon-small cell lung cancerPD-1/PD-L1

Identifiers

PMID37958458
PMCPMC10647811
OpenAlexW4388333652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.