Evidence map›Paper›PMID 37958440›Full record

ArticleCancers2023

A Novel Predictive Multi-Marker Test for the Pre-Surgical Identification of Ovarian Cancer.

Andrew N Stephens, Simon J Hobbs, Sung-Woon Kang, Maree Bilandzic, Adam Rainczuk, Martin K Oehler, Tom W Jobling, Magdalena Plebanski, Richard Allman

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06566716 (Validation of Ovarian Adnexal Mass Assessment Score Test System), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06566716 recruitingnot on this mapstarted 2024, after this paper: background citation

Validation of Ovarian Adnexal Mass Assessment Score Test System

TypeobservationalSponsorCleo Diagnostics LtdRan2024 to 2026Enrolled1,000ConditionsOvarian NeoplasmsArmsCleoDX ovarian cancer test
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Exosomes in Ovarian Cancer: Towards Precision Oncology.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Andrew N StephensHudson Institute of Medical Research, Clayton 3168, Australia.ORCID 0000-0003-2420-8458
Simon J HobbsCleo Diagnostics Ltd., Melbourne 3000, Australia.
Sung-Woon KangHudson Institute of Medical Research, Clayton 3168, Australia.
Maree BilandzicHudson Institute of Medical Research, Clayton 3168, Australia.ORCID 0000-0002-6319-1153
Adam RainczukHudson Institute of Medical Research, Clayton 3168, Australia.
Martin K OehlerDepartment of Gynecological Oncology, Royal Adelaide Hospital, Adelaide 5000, Australia.
Tom W JoblingDepartment of Gynecology Oncology, Monash Medical Centre, Bentleigh East 3165, Australia.
Magdalena PlebanskiSchool of Health and Biomedical Sciences, RMIT University, Bundoora 3083, Australia.ORCID 0000-0001-6889-3667
Richard AllmanCleo Diagnostics Ltd., Melbourne 3000, Australia.
Hudson Institute of Medical Research · AUMonash Medical Centre · AURMIT University · AURoyal Adelaide Hospital · AU

Funding

National Health and Medical Research Council APP1099375Ovarian Cancer Research Foundation OCRF-GA-2018-11Victorian Government's Operational Infrastructure Support Program n/a
6 · The paper itself

Abstract

Ovarian cancer remains the most lethal of gynecological malignancies, with the 5-year survival below 50%. Currently there is no simple and effective pre-surgical diagnosis or triage for patients with malignancy, particularly those with early-stage or low-volume tumors. Recently we discovered that CXCL10 can be processed to an inactive form in ovarian cancers and that its measurement has diagnostic significance. In this study we evaluated the addition of processed CXCL10 to a biomarker panel for the discrimination of benign from malignant disease. Multiple biomarkers were measured in retrospectively collected plasma samples (

Indexed as

benignbiomarkercancerCXCL10diagnosticmalignantovariantriage

Identifiers

PMID37958440
PMCPMC10650329
OpenAlexW4388296990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.