Evidence map›Paper›PMID 37958398›Full record

ArticleCancers2023

Phase II Trial Evaluating Olaparib Maintenance in Patients with Metastatic Castration-Resistant Prostate Cancer Responsive or Stabilized on Docetaxel Treatment: SOGUG-IMANOL Study.

María José Juan Fita, Urbano Anido Herranz, María José Mendez-Vidal, Regina Gironés-Sarrió, José Muñoz-Langa, Juan Sepúlveda-Sánchez, Begoña Mellado, Carlos Alvarez-Fernandez, Lucía Heras López, José Antonio López-Guerrero and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

María José Juan FitaFundación Instituto Valenciano de Oncología, Carrer del Professor Beltrán Báguena, 8, 46009 Valencia, Spain.ORCID 0000-0002-7767-0200
Urbano Anido HerranzMedical Oncology, Complejo Hospitalario Universitario de Santiago, 15706 Santiago de Compostela, Spain.
María José Mendez-VidalMedical Oncology, Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), Hospital Universitario Reina Sofía (HURS), 14004 Córdoba, Spain.ORCID 0000-0002-7460-1859
Regina Gironés-SarrióMedical Oncology, Hospital Universitari i Politècnic la Fe, 46026 Valencia, Spain.
José Muñoz-LangaMedical Oncology, Hospital Arnau de Vilanova, 46015 Valencia, Spain.ORCID 0000-0002-6942-8916
Juan Sepúlveda-SánchezMedical Oncology, Hospital Universitario 12 de Octubre, Instituto de Investigación 12 de Octubre, 28041 Madrid, Spain.ORCID 0000-0003-3548-9961
Begoña MelladoMedical Oncology, Hospital Clinic of Barcelona, 08036 Barcelona, Spain.ORCID 0000-0002-8088-5966
Carlos Alvarez-FernandezMedical Oncology, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.ORCID 0000-0002-2500-074X
Lucía Heras LópezServicio de Oncología Médica, Unidad de Sarcomas, Melanoma y Genitourinario, Institut Català d'Oncologia, 08908 L'Hospitalet de Llobregat, Spain.ORCID 0009-0006-4032-8774
José Antonio López-GuerreroLaboratory of Molecuar Biology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain.ORCID 0000-0002-7369-8388
Zaida García-CasadoLaboratory of Molecuar Biology, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain.ORCID 0000-0001-6592-6099
Ana CalatravaServicio Anatomía Patológica, Fundación Instituto Valenciano de Oncología, 46009 Valencia, Spain.
Miguel Ángel ClimentFundación Instituto Valenciano de Oncología, Carrer del Professor Beltrán Báguena, 8, 46009 Valencia, Spain.
Fundación Instituto Valenciano de Oncología · ESComplejo Hospitalario Universitario de Santiago · ESHospital Arnau de Vilanova · ESHospital Clínic de Barcelona · ESHospital Universitari i Politècnic La Fe · ESHospital Universitario 12 De Octubre · ESInstitut Català d'Oncologia · ESInstituto de Investigación Sanitaria del Principado de Asturias · ESInstituto Maimónides de Investigación Biomédica de Córdoba · ESUniversitat de València · ES

Funding

AstraZeneca (Spain) Not applicable
6 · The paper itself

Abstract

The SOGUG-IMANOL trial was a phase 2, uncontrolled, Spanish multicenter study to assess the effect of maintenance treatment with olaparib on radiographic progression-free survival (PFS) in patients with metastatic castration-resistant prostate cancer (mCRPC) who achieved partial or complete response or disease stabilization on docetaxel treatment and had a documented germline/somatic mutation in any of the homologous recombination repair (HRR) genes. Patients received olaparib 300 mg orally twice daily. From the screened population (

Indexed as

castration-resistant prostate cancerdocetaxelmaintenance therapyolaparib

Identifiers

PMID37958398
PMCPMC10649956
OpenAlexW4388041953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.