ArticleCancers2023
Neoadjuvant Chemotherapy plus Radical Surgery in Locally Advanced Cervical Cancer: Retrospective Single-Center Study.
Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Imaging based artificial intelligence for predicting lymph node metastasis in cervical cancer patients: a systematic review and meta-analysis.Frontiers in oncology · 2025Pooled it
- Preoperative magnetic resonance imaging-radiomics in cervical cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Survival status of women with cervical cancer in Sub-Saharan Africa: a systematic review and meta-analysis, 2024.Frontiers in oncology · 2024Pooled it
- Efficacy and safety of neoadjuvant chemotherapy followed by radical surgery vs. radical surgery alone in locally advanced cervical cancer: A systematic review and meta-analysis.Biomedical reports · 2026Article
- Effects of intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) on survival benefits and poor prognostic factors in patients with cervical cancer.Biomedical engineering online · 2025Article
- Surgical Techniques for Radical Trachelectomy.Cancers · 2025Review
- Preoperative prediction of recurrence risk factors in operable cervical cancer based on clinical-radiomics features.Frontiers in oncology · 2025Article
- Association between examined lymph node count and survival in resectable cervical cancer: a retrospective analysis using SEER data.Frontiers in oncology · 2025Article
- Comparative Analysis of Digital Transcriptomics Between Pre- and Post-Treatment Samples of Patients with Locally Advanced Cervical Cancer: A Preliminary Study.Current issues in molecular biology · 2024Article
- The Role of Lymph Node Downstaging Following Neoadjuvant Treatment in a Group of Patients with Advanced Stage Cervical Cancer.Medicina (Kaunas, Lithuania) · 2024Article
- Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis.Frontiers in immunology · 2024Article
- Elucidating prognosis in cervical squamous cell carcinoma and endocervical adenocarcinoma: a novel anoikis-related gene signature model.Frontiers in oncology · 2024Article
- Large cell neuroendocrine carcinoma of the cervix: a case report.Frontiers in oncology · 2024Article
- Lymph node assessment in cervical cancer: current approaches.Frontiers in oncology · 2024Review
- The deep learning radiomics nomogram helps to evaluate the lymph node status in cervical adenocarcinoma/adenosquamous carcinoma.Frontiers in oncology · 2024Article
- Prediction models for lymph node metastasis in cervical cancer based on preoperative heart rate variability.Frontiers in neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral pretreatment variables have been found to correlate with the clinical outcome of patients treated with NACT plus radical hysterectomy, such as FIGO stage, tumor size, and lymph node status.
methodsA single-center retrospective observational study to evaluate the use of NACT in LACC, particularly in the lymph-node-positive subpopulation. The study, conducted at the Maternal and Child Department of "Cannizzaro Hospital" in Catania, included patients treated between 2009 and 2019. Multivariate analysis was performed to analyze responses to NACT according to clinicopathologic parameters. Kaplan-Meyer disease-free survival (DFS) and overall survival (OS) curves were generated according to different lymph node status subgroups.
resultsA total of 151 consecutive patients were enrolled in the study. Significant independent risk factors for response to NACT were preoperative tumor diameter, parametrium involvement, and lymphoma vascular space invasion (LVSI). T initial diameter at NMR was found to be the independent prognostic predictor for general (
conclusionsNeoadjuvant chemotherapy followed by surgery cannot be considered a standard of care in patients with locally advanced cervical cancer, particularly in the subgroup with pre-NACT imaging suspected for LND metastases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.