Evidence map›Paper›PMID 37958327›Full record

ArticleCancers2023

Preventing Cardiotoxicity in Personalized Breast Irradiation.

Edy Ippolito, Carlo Greco, Maristella Marrocco, Carla Germana Rinaldi, Michele Fiore, Luca Eolo Trodella, Rolando Maria D'Angelillo, Sara Ramella

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Edy IppolitoRadiation Oncology, Campus Bio-Medico University Rome, 00128 Rome, Italy.
Carlo GrecoRadiation Oncology, Campus Bio-Medico University Rome, 00128 Rome, Italy.
Maristella MarroccoRadiation Oncology, Campus Bio-Medico University Rome, 00128 Rome, Italy.
Carla Germana RinaldiRadiotherapy, Department of Oncoematology, Policlinico Tor Vergata, 00133 Rome, Italy.
Michele FioreRadiation Oncology, Campus Bio-Medico University Rome, 00128 Rome, Italy.ORCID 0000-0003-1889-4578
Luca Eolo TrodellaRadiation Oncology, Campus Bio-Medico University Rome, 00128 Rome, Italy.
Rolando Maria D'AngelilloRadiotherapy, Department of Oncoematology, Policlinico Tor Vergata, 00133 Rome, Italy.
Sara RamellaRadiation Oncology, Campus Bio-Medico University Rome, 00128 Rome, Italy.ORCID 0000-0002-5782-7717
Università Campus Bio-Medico · ITPoliclinico Tor Vergata · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aims to assess the benefit of a deep inspiration breath hold (DIBH) over the standard irradiation technique, and eventually to identify anatomical and/or treatment preplanning characteristics correlated with the LAD dose.

methodsPatients with left-sided breast cancer undergoing whole breast radiotherapy with DIBH were analyzed. All patients included in the analysis had plans in DIBH and free-breathing (FB). Receiving operating characteristics (ROC analysis) were used to identify the cut-off point of parameters to predict the LAD maximum dose > 10 Gy and LAD mean dose > 4 Gy, and the areas under the curve (AUCs) were computed. Post-test probability has been performed to evaluate the effect of parameters' combination.

resultsOne hundred ninety-seven patients were analyzed. The LAD dose was significantly reduced in DIBH plans with the maximum and mean dose reduced by 31.7% (mean value 3.5 Gy vs. 4.8 Gy,

conclusionThe dosimetric advantage of DIBH is clear in all patients and DIBH should always be preferred.

Indexed as

breast cancerbreast irradiationDIBHleft descending artery

Identifiers

PMID37958327
PMCPMC10650895
OpenAlexW4388198777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.