Evidence map›Paper›PMID 37958310›Full record

ReviewCancers2023

Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms.

Maria Spanoudaki, Constantinos Giaginis, Dimitra Karafyllaki, Konstantinos Papadopoulos, Evangelos Solovos, Georgios Antasouras, Georgios Sfikas, Athanasios N Papadopoulos, Sousana K Papadopoulou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  8. Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle-tumor metabolic competition.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  16. Let-7 Family as a Mediator of Exercise on Alzheimer's Disease.Cellular and molecular neurobiology · 2025
    Review
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  18. miR-126: a bridge between cancer and exercise.Cancer cell international · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Maria SpanoudakiDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece.
Constantinos GiaginisDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece.ORCID 0000-0003-2878-4831
Dimitra KarafyllakiDepartment of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, 42132 Trikala, Greece.
Konstantinos Papadopoulos424 General Military Hospital of Thessaloniki, 54621 Thessaloniki, Greece.
Evangelos Solovos424 General Military Hospital of Thessaloniki, 54621 Thessaloniki, Greece.
Georgios AntasourasDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece.
Georgios Sfikas424 General Military Hospital of Thessaloniki, 54621 Thessaloniki, Greece.
Athanasios N PapadopoulosDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece.ORCID 0000-0002-0644-330X
Sousana K PapadopoulouDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece.ORCID 0000-0002-6408-6128
International Hellenic University · GR424 General Military Hospital · GRUniversity of the Aegean · GRUniversity of Thessaly · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer cases are continuously increasing, while the prevalence rates of physical inactivity are also continuously increasing. Physical inactivity is a causative factor in non-communicable diseases, including cancer. However, the potential beneficial effects of exercise on cancer treatment have not received much attention so far. The aim of this study was to highlight the relationship between cancer and exercise on a molecular basis.

methodsComprehensive and in-depth research was conducted in the most accurate scientific databases by using relevant and effective keywords.

resultsThe mechanisms by which exercise may reduce cancer risk and/or progression may include the metabolic profile of hormones, systemic inflammation reduction, insulin sensitivity increase, antioxidant capacity augmentation, the boost to the immune system, and the direct effect on the tumor. There is currently substantial evidence that the effect of exercise may predict a stronger association with cancer and could supplementarily be embedded in cancer clinical practice to improve disease progression and prognosis.

conclusionThe field of this study requires interconnecting the overall knowledge of exercise physiology with cancer biology and cancer clinical oncology to provide the basis for personalized targeting strategies that can be merged with training as a component of a holistic co-treatment approach to optimize cancer healthcare.

Indexed as

cancerco-treatmentexercisehormonesimmune systeminflammationmolecular mechanismsoxidative stresspersonalized strategiesprevention

Identifiers

PMID37958310
PMCPMC10648074
OpenAlexW4388265910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.