Evidence map›Paper›PMID 37958266›Full record

ArticleDiagnostics (Basel, Switzerland)2023

Percutaneous Computed Tomography-Guided Oxygen-Ozone (O

Kristina Davidovic, Sebastian Cotofana, Stephan Heisinger, Slavica Savic, Michael Alfertshofer, Tatjana Antonić, Sanja Jovanović, Marko Ercegovac, Mario Muto, Danilo Jeremić and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 7 countries.

Kristina DavidovicCenter for Radiology and Magnetic Resonance Imaging, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Sebastian CotofanaDepartment of Dermatology, Erasmus Medical Centre, 3015 GD Rotterdam, The Netherlands.
Stephan HeisingerDepartment of Orthopedics and Trauma Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Slavica SavicMedical Faculty, University of Belgrade, 11120 Belgrade, Serbia.
Michael AlfertshoferDivision of Hand, Plastic and Aesthetic Surgery, LMU University Hospital, 80336 Munich, Germany.ORCID 0000-0002-4892-2376
Tatjana AntonićCenter for Radiology and Magnetic Resonance Imaging, University Clinical Center of Serbia, 11000 Belgrade, Serbia.ORCID 0009-0001-0583-5838
Sanja JovanovićAcibadem Bel Medic, 11000 Belgrade, Serbia.
Marko ErcegovacClinic of Neurology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Mario MutoNeuroradiology Department, Ospedale Cardarelli Napoli, 80131 Napoli, Italy.
Danilo JeremićInstitute for Orthopedic Surgery "Banjica", 11000 Belgrade, Serbia.ORCID 0000-0001-5903-0878
Aleksandar JanićijevićClinic of Neurosurgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.ORCID 0009-0002-1423-1574
Lukas RasulićClinic of Neurosurgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Vesna JanoševićClinic of Neurosurgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Lidija ŠarićClinic of Neurosurgery, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Deborah ChuaMH Plastic Surgery, Singapore 238859, Singapore.
Dragan MasulovicCenter for Radiology and Magnetic Resonance Imaging, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Ružica MaksimovićCenter for Radiology and Magnetic Resonance Imaging, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Univerzitetski Klinički Centar Srbije · RSInstitute of Orthopedics Banjica · RSLMU Klinikum · DEMedical University of Vienna · ATOspedale Antonio Cardarelli · ITQueen Mary University of London · GBUniversity of Belgrade · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the effect of oxygen-ozone therapy guided by percutaneous Computed Tomography (CT) compared to corticosteroids in individuals experiencing lower back pain (LBP) not attributed to underlying bone-related issues.

methodsA total of 321 patients (192 males and 129 females, mean age: 51.5 ± 15.1 years) with LBP were assigned to three treatment groups: group A) oxygen-ozone only, group B) corticosteroids only, group C) oxygen-ozone and corticosteroids. Treatment was administered via CT-guided injections to the intervertebral disc (i.e., intradiscal location). Clinical improvement of pain and functionality was assessed via self-reported pain scales and magnetic resonance (MR) and CT imaging.

resultsAt all follow-up times, the mean score of the numeric rating scale and the total global pain scale (GPS) of study groups receiving oxygen-ozone (groups A and C) were statistically significantly lower than the study group receiving corticosteroids only (group B), with

conclusionsThe percutaneous application of oxygen-ozone in patients with LBP due to degeneration of the lumbosacral spine showed long-lasting significant pain reduction of up to two years post-treatment when compared to corticosteroids alone. Combination therapy of oxygen-ozone and corticosteroids can be useful as corticosteroids showed statistically significant improvement in LBP earlier than the oxygen-ozone-only treatment.

Indexed as

computed tomographic imagingcorticosteroidslow back painlumbosacral spinemagnet resonance imagingminimally invasive treatmentoxygen-ozone therapyozonespine degeneration

Identifiers

PMID37958266
PMCPMC10650810
OpenAlexW4388221293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.