Evidence map›Paper›PMID 37958246›Full record

ReviewDiagnostics (Basel, Switzerland)2023

Biomarkers for Prostate Cancer: From Diagnosis to Treatment.

Jia-Yan Chen, Pei-Yan Wang, Ming-Zhu Liu, Feng Lyu, Ming-Wei Ma, Xue-Ying Ren, Xian-Shu Gao

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  18. Review
  19. Overdiagnosis and Overtreatment in Prostate Cancer.Diseases (Basel, Switzerland) · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jia-Yan ChenDepartment of Radiation Oncology, Peking University First Hospital, Beijing 100034, China.
Pei-Yan WangSchool of Information, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-3696-1105
Ming-Zhu LiuClinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, China.
Feng LyuDepartment of Radiation Oncology, Peking University First Hospital, Beijing 100034, China.
Ming-Wei MaDepartment of Radiation Oncology, Peking University First Hospital, Beijing 100034, China.
Xue-Ying RenDepartment of Radiation Oncology, Peking University First Hospital, Beijing 100034, China.
Xian-Shu GaoDepartment of Radiation Oncology, Peking University First Hospital, Beijing 100034, China.ORCID 0000-0002-8348-456X
Peking University · CNFujian Medical University · CNUniversity of Michigan · US

Funding

National Natural Science Foundation of China 82271771Natural Science Foundation of Beijing Municipality 7182164Peking University First Hospital Seed Foundation 2021SF05Peking University First Hospital Seed Foundation 2021SF17Peking University Health Science Center Youth Cultivation Foundation BMU2021PYB026
6 · The paper itself

Abstract

Prostate cancer (PCa) is a widespread malignancy with global significance, which substantially affects cancer-related mortality. Its spectrum varies widely, from slow-progressing cases to aggressive or even lethal forms. Effective patient stratification into risk groups is crucial to therapeutic decisions and clinical trials. This review examines a wide range of diagnostic and prognostic biomarkers, several of which are integrated into clinical guidelines, such as the PHI, the 4K score, PCA3, Decipher, and Prolaris. It also explores the emergence of novel biomarkers supported by robust preclinical evidence, including urinary miRNAs and isoprostanes. Genetic alterations frequently identified in PCa, including BRCA1/BRCA2, ETS gene fusions, and AR changes, are also discussed, offering insights into risk assessment and precision treatment strategies. By evaluating the latest developments and applications of PCa biomarkers, this review contributes to an enhanced understanding of their role in disease management.

Indexed as

4K scorebiomarkersBRCA1/BRCA2Decipherdisease managementETS gene fusionsPCA3PHIprecision therapeuticsProlarisprostate cancer

Identifiers

PMID37958246
PMCPMC10649216
OpenAlexW4388041281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.