ArticleJournal of anatomy2024
Development of the arterial roots and ventricular outflow tracts.
Article in Journal of anatomy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Congenital Isolation of a Common Carotid Artery: A Review of Cases, Phenotypes, and Embryology of a Rare Anomaly of the Aortic Arch System.Pediatric cardiology · 2026Review
- A Spatiotemporal Single-Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- SOX6 is expressed in various cell lineages in the developing mouse heart and contributes to proper valvuloseptal development.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Longitudinal Live Imaging-Derived 4D Hemodynamics and Dynamic Tissue Mechanics Across Outflow Tract Morphogenesis.Annals of biomedical engineering · 2026Article
- Common Arterial Trunk with Intact Ventricular Septum: Morphologic and Developmental Considerations.Journal of cardiovascular development and disease · 2026Review
- Successful transcatheter closure of a congenital aorto-right ventricular fistula after Norwood procedure.JTCVS techniques · 2026Article
- Sox9 in the second heart field and the development of the outflow tract; implications for cardiac septation and valve formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Long-lasting cardiovascular responses to gestation at high altitude: lessons from a sheep model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Relating normal human cardiac development to the anatomical findings in the congenitally malformed heart.Clinical anatomy (New York, N.Y.) · 2025Review
- The Atrioventricular and Ventriculo-arterial Junctions: A Clinical Perspective for Electrophysiological and Structural Intervention. Part 1: The Atrioventricular Junctions.Arrhythmia & electrophysiology review · 2025Review
- The Atrioventricular and Ventriculo-arterial Junctions: A Clinical Perspective for Electrophysiological and Structural Intervention. Part 2: The Ventriculo-arterial Junctions.Arrhythmia & electrophysiology review · 2025Review
- Cardiac development demystified by use of the HDBR atlas.Journal of anatomy · 2024Review
- Revisiting the anatomy of the left ventricle in the light of knowledge of its development.Journal of anatomy · 2024Review
- Pulmonary Artery Dilatation Due to Pressure or Volume Overload in Congenital Heart Disease.Journal of clinical medicine · 2024Article
- Development of the arterial roots and ventricular outflow tracts.Journal of anatomy · 2024Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The separation of the outflow tract of the developing heart into the systemic and pulmonary arterial channels remains controversial and poorly understood. The definitive outflow tracts have three components. The developing outflow tract, in contrast, has usually been described in two parts. When the tract has exclusively myocardial walls, such bipartite description is justified, with an obvious dogleg bend separating proximal and distal components. With the addition of non-myocardial walls distally, it becomes possible to recognise three parts. The middle part, which initially still has myocardial walls, contains within its lumen a pair of intercalated valvar swellings. The swellings interdigitate with the distal ends of major outflow cushions, formed by the remodelling of cardiac jelly, to form the primordiums of the arterial roots. The proximal parts of the major cushions, occupying the proximal part of the outflow tract, which also has myocardial walls, themselves fuse and muscularise. The myocardial shelf thus formed remodels to become the free-standing subpulmonary infundibulum. Details of all these processes are currently lacking. In this account, we describe the anatomical changes seen during the overall remodelling. Our interpretations are based on the interrogation of serially sectioned histological and high-resolution episcopic microscopy datasets prepared from developing human and mouse embryos, with some of the datasets processed and reconstructed to reveal the specific nature of the tissues contributing to the separation of the outflow channels. Our findings confirm that the tripartite postnatal arrangement can be correlated with the changes occurring during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.