Evidence map›Paper›PMID 37957684›Full record

ArticleBMC oral health2023

Oral erythroplakia and oral erythroplakia-like oral squamous cell carcinoma - what's the difference?

Jenny Öhman, Ayelet Zlotogorski-Hurvitz, Alex Dobriyan, Shoshana Reiter, Marilena Vered, Jaana Willberg, Carlo Lajolo, Maria Siponen

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Jenny ÖhmanDepartment of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Box 450, Gothenburg, 40530, Sweden.
Ayelet Zlotogorski-HurvitzDepartment of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dentistry, Tel Aviv University, P.O. Box 39040, Tel Aviv, 6997801, Israel.
Alex DobriyanDepartment of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Derech Sheba 2, Tel Hashomer, Ramat Gan, 52621, Israel.
Shoshana ReiterDepartment of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dentistry, Tel Aviv University, P.O. Box 39040, Tel Aviv, 6997801, Israel.
Marilena VeredDepartment of Oral Pathology, Oral Medicine and Maxillofacial Imaging, School of Dentistry, Tel Aviv University, P.O. Box 39040, Tel Aviv, 6997801, Israel.
Jaana WillbergDepartment of Oral Pathology and Oral Radiology, Institute of Dentistry, Faculty of Medicine, University of Turku, University of Turku, Turku, 20014, Finland.
Carlo LajoloHead and Neck Department, School of Dentistry, "Fondazione Policlinico Universitario A. Gemelli - IRCCS", Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8, Rome, 00168, Italy.
Maria SiponenInstitute of Dentistry, University of Eastern Finland, Kuopio Campus, P.O. Box 1627, Kuopio, 70211, Finland. maria.siponen@uef.fi.
Tel Aviv University · ILRabin Medical Center · ILSheba Medical Center · ILUniversità Cattolica del Sacro Cuore · ITUniversity of Gothenburg · SEUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOral erythroplakia (OE) is a rare oral potentially malignant disorder, that has a high rate of malignant transformation. The definition of OE still lacks uniformity. In particular, lesions that look clinically like erythroplakias, but are histopathologically diagnosed as squamous cell carcinomas are still sometimes called erythroplakias. The purpose of this study is to present demographic and clinicopathologic features of a series of OEs and clinically oral erythroplakia -like squamous cell carcinomas (OELSCC), to study their differences and to discuss the definition of OE.

methodsA multicenter retrospective case series of OEs and OELSCCs. Descriptive statistics were used to analyze the data.

results11 cases of OEs and 9 cases of OELSCCs were identified. The mean age of the OE patients was 71 years and 72.7% were female, while the mean age of the OELSCC patients was 69 years, and all were female. 9% of the OE and 22% of the OELSCC patients had smoked or were current smokers. 72.7% of the OEs and 55.5% of OELSCCs were uniformly red lesions. 63.6% of the OE and 22% of the OELSCC patients had a previous diagnosis of oral lichenoid disease (OLD). The malignant transformation rate of OE was 9% in a mean of 73 months.

conclusionsOE and OELSCC may arise de novo or in association with OLD. Tobacco and alcohol use were not prevalent in the present cases. The clinical features of OEs and OELSCC are similar, but symptoms, uneven surface and ulceration may be more common in OELSCCs than in OEs. Clinical recognition of OE is important since it may mimic other, more innocuous red lesions of the oral mucosa. The diagnosis of OE requires biopsy and preferably an excision. Clarification of the definition of OE would aid in clinical diagnostics.

Indexed as

Carcinoma, Squamous CellErythroplasiaHead and Neck NeoplasmsMouth DiseasesMouth NeoplasmsOral UlcerPrecancerous ConditionsAgedFemaleHumansLeukoplakia, OralMaleMouth MucosaRetrospective StudiesSquamous Cell Carcinoma of Head and NeckErytroplakiaOral erythroplakiaOral potentially malignant disorderOral squamous cell carcinoma

Identifiers

PMID37957684
PMCPMC10644603
OpenAlexW4388630766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.