Evidence map›Paper›PMID 37957532›Full record

ReviewHepatology international2024

Intrahepatic cholestasis of pregnancy: insights into pathogenesis and advances in omics studies.

Mi Tang, Liling Xiong, Jianghui Cai, Jinzhu Fu, Hong Liu, Ying Ye, Li Yang, ShaSha Xing, Xiao Yang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
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  11. A RareJournal of clinical medicine · 2025
    Article
  12. Article
  13. Intrahepatic cholestasis of pregnancy.Nature reviews. Disease primers · 2025
    Review
  14. Article
  15. Article
  16. Bile acids as therapeutic agents.Frontiers in pharmacology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mi Tang *GCP Institution, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Liling Xiong *Obstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Jianghui Cai *Department of Pharmacy, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Jinzhu FuObstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Hong LiuOperating Theater, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Ying YeOperating Theater, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Li YangObstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China.
ShaSha XingGCP Institution, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China. xingshasha1230@126.com.
Xiao YangObstetrics Department, School of Medicine, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, 611731, China. wcchgcptg@163.com.ORCID http://orcid.org/0000-0001-9805-221X
University of Electronic Science and Technology of China · CNChengdu Women's and Children's Central Hospital · CN

Funding

Chengdu Medical Research Project 2022065Chengdu Women's and Children's Central Hospital Talent Program YC2022010Foundation of key research and development project of Sichuan Province 2022YFS0227Foundation of Project of Chengdu Women and Children's Central Hospital 2022JC01
6 · The paper itself

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-specific liver disease. It is characterized by pruritus, abnormal liver function and elevated total bile acid (TBA) levels, increasing the risk of maternal and fetal adverse outcomes. Its etiology remains poorly elucidated. Over the years, various omics techniques, including metabolomics, microbiome, genomics, etc., have emerged with the advancement of bioinformatics, providing a new direction for exploring the pathogenesis, diagnosis and treatment of ICP. In this review, we first summarize the role of bile acids and related components in the pathogenesis of ICP and then further illustrate the results of omics studies.

Indexed as

Cholestasis, IntrahepaticPregnancy ComplicationsBile Acids and SaltsFemaleHumansPregnancyBile Acids and SaltsBile acidBile acid receptorGeneGenomicsGut microbiotaHormoneIntrahepatic cholestasis of pregnancyLipidMetabolomicsMicrobiome

Identifiers

PMID37957532
OpenAlexW4388623546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.