Evidence map›Paper›PMID 37957522›Full record

ArticleAdvances in therapy2024

Real-World Experience of Adalimumab Biosimilar (ABP 501) Use in Patients with Inflammatory Bowel Disease in Europe.

Ran Jin, Chidozie Nduka, Delphine Courmier, Hannah Knight, Rachael Meadows, James Piercy, J R F Cummings, Waldemar Radziszewski

Abstract read
In one paragraph

Article in Advances in therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Current status and trends of anti-tumor biosimilars in China from 2019 to 2023: A cross-sectional analysis.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Article
  5. Article
  6. Switching from Adalimumab Reference Product to and Among Adalimumab Biosimilars Outside the USA: Insights for US Clinicians.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  7. Article
  8. Review
  9. Observational
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ran JinAmgen Inc., Thousand Oaks, CA, USA. rjin01@amgen.com.ORCID 0000-0002-0245-9187
Chidozie NdukaAmgen Inc., Thousand Oaks, CA, USA.ORCID 0000-0001-7031-5444
Delphine CourmierAmgen Inc., Thousand Oaks, CA, USA.ORCID 0009-0003-4436-1537
Hannah KnightAdelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington, Macclesfield, SK10 5JB, Cheshire, UK. hannah.knight@adelphigroup.com.ORCID 0000-0002-8379-4381
Rachael MeadowsAdelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington, Macclesfield, SK10 5JB, Cheshire, UK.ORCID 0000-0001-9047-4733
James PiercyAdelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington, Macclesfield, SK10 5JB, Cheshire, UK.ORCID 0000-0001-7015-1021
J R F CummingsDepartment of Gastroenterology, University Hospital Southampton NHS Foundation Trust, Southampton, UK.ORCID 0000-0002-9659-3247
Waldemar RadziszewskiAmgen Inc., Thousand Oaks, CA, USA.ORCID 0000-0001-5254-7436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionApproval of adalimumab biosimilar ABP 501 (Amgevita

methodsData were drawn from the 2020-2021 Adelphi IBD Disease Specific Programme™ conducted in five major European countries. Participating gastroenterologists completed a point-in-time survey to provide patient medical record data, and patients voluntarily completed questionnaires to report health-related quality of life (HRQoL). Descriptive analyses were conducted for "ABP 501 initiators" (received ABP 501 as first advanced therapy) and "RP-ABP 501 switchers" (switched to ABP 501 from reference product [RP; Humira

resultsThis analysis included 239 ABP 501 initiators and 136 RP-ABP 501 switchers. At consultation, initiators had been on ABP 501 treatment for a median of 7.5 months and switchers had received ABP 501 for a median of 7.7 months following the switch from a median of 14.0 months treatment with RP. About 74% of initiators and 89% of switchers were reported by their treating physicians as being in clinical remission. Physicians and patients reported satisfaction with ABP 501 in the range of 92-99% across both groups. Patient self-assessment, including EuroQol visual analogue scale, Short IBD Questionnaire, and Work Productivity and Activity Impairment scores, suggested minimal impairment of HRQoL while on ABP 501. The most common reason for RP to ABP 501 switch was lower healthcare costs.

conclusionBoth patients with IBD and treating physicians reported high levels of satisfaction with ABP 501 among initiators and switchers.

Indexed as

Biosimilar PharmaceuticalsInflammatory Bowel DiseasesAdalimumabEuropeHumansQuality of LifeTreatment OutcomeABP 501AdalimumabBiosimilar PharmaceuticalsAdalimumabBiosimilarInflammatory bowel diseasesReal-world

Identifiers

PMID37957522
PMCPMC10796661

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.