ArticleJournal of the Association for Research in Otolaryngology : JARO2023
Neural Degeneration in Normal-Aging Human Cochleas: Machine-Learning Counts and 3D Mapping in Archival Sections.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: I. Cochlear nerve responsiveness and electrode-neuron interface index.Hearing research · 2026Article
- Cochlear aging after synaptopathic noise: age-noise interactions in hair cell loss and axonal degeneration.Hearing research · 2026Article
- Cochlear Neural Degeneration Is Widespread in Ménière's Disease: A Temporal Bone Study.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Evaluating the N1-P2 Interpeak Latency of the eCAP and Its Intertrial Variability as Potential Indicators of Neural Synchrony in the Auditory Nerve of Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Electrically evoked compound action potentials in adult and pediatric cochlear implant users: II. Assessing cochlear nerve health status with the interphase gap effect and the phase locking value.Hearing research · 2026Article
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Cochlear neural degeneration is key to the variation in word scores among people with similar thresholds.Hearing research · 2026Article
- Peripheral Neural Plasticity in Cochlear Implant Users Across the Lifespan.JAMA otolaryngology-- head & neck surgery · 2026Article
- Establishing reliable neural health measures in adult cochlear implant users.Frontiers in neuroscience · 2026Article
- Ultrastructural Synaptic Differences in the Central Inferior Colliculus in the 3xTG Mouse Across Three Disease Stages.The Journal of comparative neurology · 2025Article
- Evaluating the N1-P2 interpeak latency of the eCAP and its intertrial variability as potential indicators of neural synchrony in the cochlear nerve of cochlear implant users.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Spiner, deep learning-based automated detection of spiral ganglion neurons in intact cochleae.iScience · 2025Article
- Polarity sensitivity to symmetric, biphasic monopolar pulses is not a reliable indicator of peripheral axonal degeneration in human cochlear implant users.Frontiers in audiology and otology · 2025Article
- Simulated auditory nerve response evoked by lateral-wall and peri-modiolar electrode arrays inserted in scala tympani or scala vestibuli.Frontiers in neuroscience · 2025Article
- Delayed hearing loss after cochlear implantation: Re-evaluating the role of hair cell degeneration.Hearing research · 2024Article
- Article
- The Failure Index as Marker of the Neural Health Profile in MED-EL CI Users: A Retrospective Analysis.Trends in hearingArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Quantifying the survival patterns of spiral ganglion cells (SGCs), the cell bodies of auditory-nerve fibers, is critical to studies of sensorineural hearing loss, especially in human temporal bones. The classic method of manual counting is tedious, and, although stereology approaches can be faster, they can only be used to estimate total cell numbers per cochlea. Here, a machine-learning algorithm that automatically identifies, counts, and maps the SGCs in digitized images of semi-serial human temporal-bone sections not only speeds the analysis, with no loss of accuracy, but also allows 3D visualization of the SGCs and fine-grained mapping to cochlear frequency. Applying the algorithm to 62 normal-aging human ears shows significantly faster degeneration of SGCs in the basal than the apical half of the cochlea. Comparison to fiber counts in the same ears shows that the fraction of surviving SGCs lacking a peripheral axon steadily increases with age, reaching more than 50% in the apical cochlea and almost 66% in basal regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.