Evidence map›Paper›PMID 37957471›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

Nicotinamide Riboside, an NAD + Precursor, Protects Against Cardiac Mitochondrial Dysfunction in Fetal Guinea Pigs Exposed to Gestational Hypoxia.

Loren P Thompson, Hong Song, Jamie Hartnett

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Loren P ThompsonDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA. lthompson1@umm.edu.ORCID 0000-0003-1693-3617
Hong SongDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA.
Jamie HartnettDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland, Baltimore, School of Medicine, 655 W. Baltimore St., Baltimore, MD, 21201, USA.
University of Maryland, Baltimore · US

Funding

Impact of Prenatal Hypoxia on Mitochondrial Function of Offspring HeartsR01HL126859 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, EUGENE D. · 2015 to 2022
$3.7M
NHLBI NIH HHS R01 HL126859NHLBI NIH HHS R56 HL126859
6 · The paper itself

Abstract

Gestational hypoxia inhibits mitochondrial function in the fetal heart and placenta contributing to fetal growth restriction and organ dysfunction. NAD + deficiency may contribute to a metabolic deficit by inhibiting oxidative phosphorylation and ATP synthesis. We tested the effects of nicotinamide riboside (NR), an NAD + precursor, as a treatment for reversing known mitochondrial dysfunction in hypoxic fetal hearts. Pregnant guinea pigs were housed in room air (normoxia) or placed in a hypoxic chamber (10.5%O

Indexed as

Mitochondrial DiseasesPyridinium CompoundsSirtuin 3Adenosine TriphosphateAnimalsFemaleFetal HeartFetal HypoxiaGuinea PigsHumansHypoxiaMaleMitochondriaNADNiacinamidePregnancyAdenosine TriphosphateNADNiacinamidenicotinamide-beta-ribosidePyridinium CompoundsSirtuin 3AcetylationFetusHeartHypoxiaMitochondriaNADNicotinamidePlacentaSirtuin

Identifiers

PMID37957471
PMCPMC10959782
OpenAlexW4388625084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.