Evidence map›Paper›PMID 37957388›Full record

ArticleLung2023

A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension.

Justin K Lui, Kari R Gillmeyer, Ruchika A Sangani, Robert J Smyth, Deepa M Gopal, Marcin A Trojanowski, Andreea M Bujor, Renda Soylemez Wiener, Michael P LaValley, Elizabeth S Klings

Open access · greenAbstract read
In one paragraph

Article in Lung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Justin K LuiThe Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, R‑304, Boston, MA, 02118, USA. justin.lui@bmc.org.ORCID 0000-0002-4745-3766
Kari R GillmeyerThe Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, R‑304, Boston, MA, 02118, USA.ORCID 0000-0002-5333-259X
Ruchika A SanganiThe Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, R‑304, Boston, MA, 02118, USA.ORCID 0000-0003-1982-4408
Robert J SmythThe Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, R‑304, Boston, MA, 02118, USA.ORCID 0000-0001-7613-9306
Deepa M GopalSection of Cardiovascular Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0003-3534-9360
Marcin A TrojanowskiSection of Rheumatology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0003-2583-1591
Andreea M BujorSection of Rheumatology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-8840-8937
Renda Soylemez WienerThe Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, R‑304, Boston, MA, 02118, USA.ORCID 0000-0001-7712-2135
Michael P LaValleySection of Rheumatology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0002-8488-5170
Elizabeth S KlingsThe Pulmonary Center, Boston University Chobanian & Avedisian School of Medicine, 72 East Concord Street, R‑304, Boston, MA, 02118, USA.ORCID 0000-0003-4879-720X
Boston University · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Research and Evaluation Support Core Unit (RESCU Core)P30AR072571 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Paul Lavalley · 2019 to 2026
$6.9M
The role of Fli1 in myeloid cells and its contribution to cardiac fibrosisR01HL155955 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BUJOR, ANDREEA MONICA · 2021 to 2025
$2.1M
1/2 Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE Trial)UG3HL143192 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T, TRIULZI, DARRELL J · 2019 to 2019
$1.5M
Doris Duke Charitable Foundation 2021261HRSA HHS U1EMC27864-08-00NCATS NIH HHS 1UL1TR001430NCATS NIH HHS UL1 TR001430NHLBI NIH HHS 1R01HL155955-01A1NHLBI NIH HHS 1UG3 HL143192-01A1NHLBI NIH HHS R01 HL155955NHLBI NIH HHS UG3 HL143192NIAMS NIH HHS CCCR P30 AR072571NIAMS NIH HHS P30 AR072571
6 · The paper itself

Abstract

We devised a scoring system to identify patients with systemic sclerosis (SSc) at risk for pulmonary hypertension (PH) and predict all-cause mortality. Using 7 variables obtained via pulmonary function testing, echocardiography, and computed tomographic chest imaging, we applied the score to a retrospective cohort of 117 patients with SSc. There were 60 (51.3%) who were diagnosed with PH by right heart catheterization. Using a scoring threshold ≥ 0, our decision tool predicted PH with a sensitivity, specificity, and accuracy of 0.87 (95% CI 0.75, 0.94), 0.74 (95% CI 0.60, 0.84), and 0.80 (95% CI 0.72, 0.87), respectively. When adjusted for age at PH diagnosis, sex, and receipt of pulmonary arterial vasodilators, each one-point score increase was associated with an adjusted HR of 1.19 (95% CI 1.05, 1.34) for all-cause mortality. With further validation in external cohorts, our simplified clinical decision tool may better streamline earlier detection of PH in SSc.

Indexed as

Hypertension, PulmonaryScleroderma, SystemicCardiac CatheterizationEchocardiographyHumansRetrospective StudiesClinical prediction ruleConnective tissue diseaseDiffuse sclerodermaLimited sclerodermaPulmonary arteryPulmonary function test

Identifiers

PMID37957388
PMCPMC11037922
OpenAlexW4388625941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.