Evidence map›Paper›PMID 37957354›Full record

ArticleNature immunology2023

Microbial ligand-independent regulation of lymphopoiesis by NOD1.

Chiaki Iwamura, Hidetaka Ohnuki, Francis A Flomerfelt, Lixin Zheng, Alexie Carletti, Hidefumi Wakashin, Yohei Mikami, Stephen R Brooks, Yuka Kanno, Ronald E Gress and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Role and molecular mechanism of NOD2 in chronic non-communicable diseases.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Chiaki IwamuraImmunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.
Hidetaka OhnukiLaboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA.ORCID 0000-0001-8951-3264
Francis A FlomerfeltExperimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, USA.
Lixin ZhengMolecular Development of the Immune System Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Alexie CarlettiImmunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.
Hidefumi WakashinKidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Yohei MikamiMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5104-4415
Stephen R BrooksBiodata Mining and Discovery Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5592-5332
Yuka KannoMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-5668-9319
Ronald E GressExperimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD, USA.
Giovanna TosatoLaboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD, USA.
Toshinori NakayamaChiba University, Chiba, Japan.ORCID 0000-0002-1434-2007
John J O'SheaMolecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.
Alan SherImmunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0001-7053-2895
Dragana JankovicImmunobiology Section, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, Bethesda, MD, USA. DJankovic@niaid.nih.gov.ORCID 0000-0001-7360-1809
National Institutes of Health · USNational Cancer Institute · USNational Institute of Allergy and Infectious Diseases · USChiba University · JP

Funding

Intramural NIH HHS Z99 AR999999
6 · The paper itself

Abstract

Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1, a cytosolic innate sensor of bacterial peptidoglycan, also functions in murine hematopoietic cells as a major regulator of both the generation and differentiation of lymphoid progenitors as well as peripheral T lymphocyte homeostasis. We further show that NOD1 mediates these functions by facilitating STAT5 signaling downstream of hematopoietic cytokines. In steady-state, loss of NOD1 resulted in a modest but significant decrease in numbers of mature T, B and natural killer cells. During systemic protozoan infection this defect was markedly enhanced, leading to host mortality. Lack of functional NOD1 also impaired T cell-dependent anti-tumor immunity while preventing colitis. These findings reveal that, in addition to its classical role as a bacterial ligand receptor, NOD1 plays an important function in regulating adaptive immunity through interaction with a major host cytokine signaling pathway.

Indexed as

Immunity, InnateLymphopoiesisAnimalsColitisLigandsMiceNod1 Signaling Adaptor ProteinSignal TransductionLigandsNod1 protein, mouseNod1 Signaling Adaptor Protein

Identifiers

PMID37957354
PMCPMC12667175
OpenAlexW4388625723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.