ArticleNature neuroscience2023
Meta-reinforcement learning via orbitofrontal cortex.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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The trial behind it
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Who cites it
28 citing papers in PubMed.
- Article
- Article
- Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Tower Foraging Park: A paradigm for studying cognitive and motor processes underlying behavioral flexibility in freely moving mice.iScience · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Renovating the Barnes maze for mouse models of dementia with STARR FIELD: A 4-day protocol for learning rate, retention, and cognitive flexibility.Methods (San Diego, Calif.) · 2026Article
- Adaptive reorganization of history encoding in the retrosplenial cortex supports flexible decision-making strategies.Neuron · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Cell-type-specific sustained value representations in the claustrum.bioRxiv : the preprint server for biology · 2026Article
- Brain-inspired energy efficient technologies for next-generation artificial intelligence.Biological cybernetics · 2026Review
- Submedius thalamic inputs shape the presynaptic architecture of layer 5 orbitofrontal cortex in mice.iScience · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Time-dependent deployment of medial prefrontal cortical representations in male mice.Nature communications · 2026Article
- Neural basis of cooperative behavior in biological and artificial intelligence systems.Science (New York, N.Y.) · 2026Article
- VTA dopamine neuron activity produces spatially organized value representations.bioRxiv : the preprint server for biology · 2025Article
- Human Strategy Adaptation in Reinforcement Learning Resembles Policy Gradient Ascent.bioRxiv : the preprint server for biology · 2025Article
- Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex.Nature communications · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
The meta-reinforcement learning (meta-RL) framework, which involves RL over multiple timescales, has been successful in training deep RL models that generalize to new environments. It has been hypothesized that the prefrontal cortex may mediate meta-RL in the brain, but the evidence is scarce. Here we show that the orbitofrontal cortex (OFC) mediates meta-RL. We trained mice and deep RL models on a probabilistic reversal learning task across sessions during which they improved their trial-by-trial RL policy through meta-learning. Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.