Evidence map›Paper›PMID 37956741›Full record

Trial reportThe journal of pain2024

Exploring HD-tDCS Effect on μ-opioid Receptor and Pain Sensitivity in Temporomandibular Disorder: A Pilot Randomized Clinical Trial Study.

Dajung J Kim, Thiago D Nascimento, Manyoel Lim, Theodora Danciu, Jon-Kar Zubieta, Peter J H Scott, Robert Koeppe, Niko Kaciroti, Alexandre F DaSilva

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. High-definition tDCS over primary motor cortex modulates brain signal variability and functional connectivity in episodic migraine.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Trial
  3. Review
  4. Article
  5. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dajung J KimHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan.
Thiago D NascimentoHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan.
Manyoel LimFood Processing Research Group, Food Convergence Research Division, Korea Food Research Institute, Jeollabuk-do, Republic of Korea.
Theodora DanciuDepartment of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Jon-Kar ZubietaDepartment of Psychiatry, Mass General Brigham, Newton-Wellesley Hospital, Newton, Massachusetts.
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.
Robert KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, Michigan.
Niko KacirotiDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Alexandre F DaSilvaHeadache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan.
University of Michigan · USKorea Food Research Institute · KRNewton Wellesley Hospital · US

Funding

Investigation and Modulation of the Central Mu-Opioid Mechanism in Migraine (in vivo)R01NS094413 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALEXANDRE DASILVA · 2015 to 2026
$4.3M
Investigation and Modulation of the Mu-Opioid Mechanism in Chronic TMD (in vivo)U01DE025633 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2016 to 2020
$2.4M
Brain as a Research and Therapeutic Target in Chronic TMDR56DE022637 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DASILVA, ALEXANDRE · 2013 to 2014
$773k
NIDCR NIH HHS R56 DE022637NIDCR NIH HHS U01 DE025633NINDS NIH HHS R01 NS094413
6 · The paper itself

Abstract

This study explored the association between experimentally-induced pain sensitivity and µ-opioid receptor (μOR) availability in patients with temporomandibular disorder (TMD) and further investigated any changes in the pain and μOR availability following high-definition transcranial direct current stimulation (HD-tDCS) over the primary motor cortex (M1) with pilot randomized clinical trials. Seven patients with TMD completed either active (n = 3) or sham treatment (n = 4) for 10 daily sessions and underwent positron emission tomography (PET) scans with [

Indexed as

Temporomandibular Joint DisordersTranscranial Direct Current StimulationHumansPainPain ThresholdPilot ProjectsBrain stimulationHD-tDCSLimbic systemTemporomandibular disorderµ-opioid receptor

Identifiers

PMID37956741
PMCPMC11705548
OpenAlexW4388591053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.