Evidence map›Paper›PMID 37956733›Full record

ArticleThe Journal of allergy and clinical immunology2024

Chemokine CCL19 promotes type 2 T-cell differentiation and allergic airway inflammation.

Keiko Nakano, Gregory S Whitehead, Miranda R Lyons-Cohen, Sara A Grimm, Christina L Wilkinson, Gentaro Izumi, Alessandra Livraghi-Butrico, Donald N Cook, Hideki Nakano

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  7. Airway epithelial heterogeneity and mucus plugging in asthmatic bronchioles.American journal of respiratory and critical care medicine · 2026
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  9. Review
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  11. Systemic inflammatory biomarkers in relation to lung function and exercise-induced bronchoconstriction in adolescents.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Keiko NakanoImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Gregory S WhiteheadImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Miranda R Lyons-CohenImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Sara A GrimmIntegrative Bioinformatics Support Group, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Christina L WilkinsonImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Gentaro IzumiImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.
Alessandra Livraghi-ButricoMarsico Lung Institute, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.
Donald N CookImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC. Electronic address: cookd@niehs.nih.gov.
Hideki NakanoImmunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC. Electronic address: nakanoh@niehs.nih.gov.
National Institutes of Health · USUniversity of North Carolina at Chapel Hill · US

Funding

Allergic sensitization through the airwayZIAES102025 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COOK, DONALD N · 2009 to 2025
$32.6M
genetic requirements of allergic responses in the lungZ01ES102025 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI COOK, DONALD N · 2006 to 2008
$3.4M
Host microbiota and airway mucus: a novel paradigm for lung defense and immune homeostasis during early post-natal developmentR01HL150541 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIVRAGHI-BUTRICO, ALESSANDRA MARIA · 2020 to 2023
$1.5M
AHRQ HHS R01 HS015054Intramural NIH HHS Z01 ES102025Intramural NIH HHS ZIA ES102025NHLBI NIH HHS R01 HL150541
6 · The paper itself

Abstract

backgroundAllergic asthma is driven largely by allergen-specific T

objectiveThis study sought to define the role of CCL19 in T

methodsCcl19-deficient mice were studied in an animal model of allergic asthma. Dendritic cells or fibroblastic reticular cells from wild-type and Ccl19-deficient mice were cultured with naive CD4

resultsLungs of Ccl19-deficient mice had less allergic airway inflammation, reduced airway hyperresponsiveness, and less IL-4 and IL-13 production compared with lungs of Ccl19-sufficient animals. Naive CD4

conclusionsThese results reveal a novel, T

Indexed as

AsthmaHypersensitivityAllergensAnimalsCell DifferentiationChemokine CCL19Dendritic CellsInflammationLigandsLungMiceReceptors, CCR7Th2 CellsAllergensChemokine CCL19LigandsReceptors, CCR7AsthmaCCL19dendritic cellsfibroblastic reticular cellsIL-2STAT5T(H)2 cells

Identifiers

PMID37956733
PMCPMC10922373
OpenAlexW4388591253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.