ArticleEuropean heart journal2024
Dynamic electrocardiogram changes are a novel risk marker for sudden cardiac death.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Obstructive sleep apnea and the risk of sudden cardiac death: a systematic review and meta-analysis.BMC cardiovascular disorders · 2025Pooled it
- Application of Machine Learning for Patients With Cardiac Arrest: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Dynamic Risk Trajectories for Sudden Cardiac Arrest: The Role of Recurrent Cardiovascular Events.Journal of the American Heart Association · 2026Observational
- Performance of the 12-lead ECG in predicting short- and long-term risk of sudden cardiac death.NPJ digital medicine · 2026Article
- Floppy Mitral Valve/Mitral Valve Prolapse: Diagnosis and Clinical Classification in This Continuing Odyssey.European cardiology · 2026Review
- Observational
- Electrical Risk Score as a Predictor of Coronary Artery Disease.Journal of clinical medicine · 2025Article
- Dynamic Risk Trajectories for Sudden Cardiac Arrest: The Role of Recurrent Cardiovascular Events.medRxiv : the preprint server for health sciences · 2025Article
- Temporal trends in left ventricular ejection fraction before sudden death in patients with heart failure.Heart rhythm · 2025Article
- Prognostic Significance of AI-Enhanced ECG for Emergency Department Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Cardiac Clues in Major Depressive Disorder: Evaluating Electrical Risk Score as a Predictive Electrocardiography Biomarker.Medicina (Kaunas, Lithuania) · 2025Article
- Evaluation of electrocardiographic alterations before and after bariatric surgery.Global cardiology science & practice · 2025Article
- Top stories: Cardiac arrest-Patients at risk.Heart rhythm · 2025Article
- The Association of Electrical Risk Score with Prognosis in Patients with Non-ST Elevation Myocardial Infarction Undergoing Coronary Angiography.Anatolian journal of cardiology · 2024Article
- Recent Advances in Wearable Healthcare Devices: From Material to Application.Bioengineering (Basel, Switzerland) · 2024Review
- Ventricular fibrillation and the proteome problem: can we solve it?European heart journal. Acute cardiovascular care · 2024Article
- Sudden cardiac arrest: Limitations in risk-stratification and treatment, and the potential for digital technologies and artificial intelligence to improve prediction and outcomes.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsElectrocardiogram (ECG) abnormalities have been evaluated as static risk markers for sudden cardiac death (SCD), but the potential importance of dynamic ECG remodelling has not been investigated. In this study, the nature and prevalence of dynamic ECG remodelling were studied among individuals who eventually suffered SCD.
methodsThe study population was drawn from two prospective community-based SCD studies in Oregon (2002, discovery cohort) and California, USA (2015, validation cohort). For this present sub-study, 231 discovery cases (2015-17) and 203 validation cases (2015-21) with ≥2 archived pre-SCD ECGs were ascertained and were matched to 234 discovery and 203 validation controls based on age, sex, and duration between the ECGs. Dynamic ECG remodelling was measured as progression of a previously validated cumulative six-variable ECG electrical risk score.
resultsOregon SCD cases displayed greater electrical risk score increase over time vs. controls [+1.06 (95% confidence interval +0.89 to +1.24) vs. -0.05 (-0.21 to +0.11); P < .001]. These findings were successfully replicated in California [+0.87 (+0.7 to +1.04) vs. -0.11 (-0.27 to 0.05); P < .001]. In multivariable models, abnormal dynamic ECG remodelling improved SCD prediction over baseline ECG, demographics, and clinical SCD risk factors in both Oregon [area under the receiver operating characteristic curve 0.770 (95% confidence interval 0.727-0.812) increased to area under the receiver operating characteristic curve 0.869 (95% confidence interval 0.837-0.902)] and California cohorts.
conclusionsDynamic ECG remodelling improved SCD risk prediction beyond clinical factors combined with the static ECG, with successful validation in a geographically distinct population. These findings introduce a novel concept of SCD dynamic risk and warrant further detailed investigation.
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Registered trials
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