Evidence map›Paper›PMID 37955814›Full record

ArticleFrontiers of medicine2024

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis.

Weiwei Xian, Mohammad Asad, Shuai Wu, Zhixin Bai, Fengjiao Li, Junfeng Lu, Gaoyu Zu, Erin Brintnell, Hong Chen, Ying Mao and 5 more

Erratum issuedOpen access · hybridAbstract read
PubMed Publisher
In one paragraph

Article in Frontiers of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Weiwei Xian *Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Mohammad Asad *Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.
Shuai Wu *Glioma Surgery Division, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhixin Bai *Department of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Fengjiao LiDepartment of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Junfeng LuGlioma Surgery Division, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Gaoyu ZuDepartment of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Erin BrintnellCumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.
Hong ChenDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ying MaoDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Guomin ZhouDepartment of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Bo LiaoSchool of Mathematics and Statistics, Hainan Normal University, Haikou, 570100, China.
Jinsong WuGlioma Surgery Division, Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. wujinsong@huashan.org.cn.
Edwin WangCumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. edwin.wang@ucalgary.ca.
Linya YouDepartment of Human Anatomy & Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. lyyou@fudan.edu.cn.
Fudan University · CNHuashan Hospital · CNUniversity of Calgary · CAHainan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association of neurogenesis and gliogenesis with glioma remains unclear. By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive oligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in a public cohort and TCGA glioma. The RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations, and the pri-OPC-like ones were prone to carrying TP53 mutations. Tumor subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes, suggesting their distinct immune evasion programs. Furthermore, the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct manners. Some specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytes. For example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes, respectively. Their expression was positively correlated with those of immune checkpoint genes (e.g., LGALS33) and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat cells. This finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

Indexed as

Brain NeoplasmsGliomaEpendymoglial CellsHumansMutationReceptor-Like Protein Tyrosine Phosphatases, Class 5Single-Cell Gene Expression AnalysisTumor MicroenvironmentPTPRZ1 protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 5gliomaimmune escapeprimitive oligodendrocyte precursor cellradial gliasingle-cell RNA-seq

Identifiers

PMID37955814
OpenAlexW4388635535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.