Evidence map›Paper›PMID 37955792›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors.

Dongyoul Lee, Mengshi Li, Dijie Liu, Nicholas J Baumhover, Edwin A Sagastume, Brenna M Marks, Prerna Rastogi, F Christopher Pigge, Yusuf Menda, Frances L Johnson and 1 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  2. Article
  3. Article
  4. Emerging Theranostic Radiometals (Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  5. PreclinicalJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  6. Review
  7. A Phase 0 Imaging Trial of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  8. Single Photon Emission Computed Tomography Tracer.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  9. Minimising the impact of stableEJNMMI radiopharmacy and chemistry · 2025
    Article
  10. EJNMMI radiopharmacy and chemistry · 2025
    Review
  11. Review
  12. Article
  13. Side-by-Side Comparison of the In Vivo Performance of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dongyoul LeeDepartment of Physics and Chemistry, Korea Military Academy, Seoul, Republic of Korea.
Mengshi LiPerspective Therapeutics, Inc., Coralville, IA, USA.
Dijie LiuPerspective Therapeutics, Inc., Coralville, IA, USA.
Nicholas J BaumhoverPerspective Therapeutics, Inc., Coralville, IA, USA.
Edwin A SagastumePerspective Therapeutics, Inc., Coralville, IA, USA.
Brenna M MarksPerspective Therapeutics, Inc., Coralville, IA, USA.
Prerna RastogiDepartment of Pathology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
F Christopher PiggeDepartment of Chemistry, The University of Iowa, ML B180 FRRBP, 500 Newton Road, Iowa City, IA, 52240, USA.
Yusuf MendaDepartment of Radiology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Frances L JohnsonPerspective Therapeutics, Inc., Coralville, IA, USA.
Michael K SchultzPerspective Therapeutics, Inc., Coralville, IA, USA. michael-schultz@uiowa.edu.
University of Iowa Hospitals and Clinics · USKorea Military Academy · KRUniversity of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Project 4: New Approaches to Improving the Effectiveness of Radionuclide Targeted Treatments in Neuroendocrine TumorsP50CA174521 · NCI · UNIVERSITY OF IOWA · PI MENDA, YUSUF · 2015 to 2021
$13.2M
Alpha-Particle Emitter Peptide Receptor Targeted Radionuclide Therapy for Neuroendocrine TumorsR01CA243014 · NCI · UNIVERSITY OF IOWA · PI MENDA, YUSUF · 2019 to 2024
$2.5M
GMP peptide manufacturing, pharmacology/toxicology, and scaled radionuclide production and validation for Pb-212 receptor targeted alpha-particle therapy clinical trials for metastatic melanoma.R44CA254613 · NCI · VIEWPOINT MOLECULAR TARGETING, INC. · PI SCHULTZ, MICHAEL KING · 2020 to 2021
$2.0M
Preclinical pharmacology, toxicology, biodistribution and dosimetry, and radionuclide production CMC validation for Pb-212 receptor targeted alpha-particle therapy for neuroendocrine tumors.R44CA250872 · NCI · VIEWPOINT MOLECULAR TARGETING, INC. · PI SCHULTZ, MICHAEL KING · 2020 to 2021
$2.0M
Image-guided dosimetry-based alpha particle therapy for neuroblastoma.R44CA268314 · NCI · VIEWPOINT MOLECULAR TARGETING, INC. · PI PACKARD, ALAN BRENT, SCHULTZ, MICHAEL KING · 2022 to 2023
$2.0M
NCI NIH HHS P30 CA086862NCI NIH HHS P50 CA174521NCI NIH HHS R01 CA243014NCI NIH HHS R44 CA250872NCI NIH HHS R44 CA254613NCI NIH HHS R44 CA268314NIEHS NIH HHS P30 ES005605NINR NIH HHS R44CA250872
6 · The paper itself

Abstract

purposeThe lead-203 (

methodsNew SSTR2-targeted peptides were designed and synthesized with the goal of optimizing the incorporation of Pb isotopes through the use of a modified cyclization technique; the introduction of a Pb-specific chelator (PSC); and the insertion of polyethylene glycol (PEG) linkers. The binding affinity of the peptides and the cellular uptake of

resultsThe lead radiopeptide drug conjugate (RPDC) - [

conclusionStructural modifications to chelator and linker compositions improved tumor targeting and pharmacokinetics (PK) of

Indexed as

Neuroendocrine TumorsOctreotideAnimalsChelating AgentsHumansLeadLead RadioisotopesMiceRadiopharmaceuticalsReceptors, SomatostatinTissue DistributionChelating AgentsLeadLead-203Lead-212Lead RadioisotopesOctreotideRadiopharmaceuticalsReceptors, SomatostatinAlpha-particle therapyLead isotopesPeptidesPRRTSSTR2Structural optimization

Identifiers

PMID37955792
PMCPMC10881741
OpenAlexW4388633913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.