In silico designing of an epitope-based peptide vaccine cocktail against Nipah virus: an Indian population-based epidemiological study.

Dwaipayan Chaudhuri, Satyabrata Majumder, Joyeeta Datta, Kalyan Giri

Abstract read

In one paragraph

Article in Archives of microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 69% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dwaipayan ChaudhuriDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Satyabrata MajumderDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Joyeeta DattaDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India.

Kalyan GiriDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, India. kalyan.dbs@presiuniv.ac.in.ORCID http://orcid.org/0000-0001-5681-2612

Presidency University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nipah virus, a zoonotic virus from the family Paramyxoviridae has led to significant loss of lives till date with the most recent outbreak in India reported in Kerala. The virus has a considerably high mortality rate along with lack of characteristic symptoms which results in the delay of the virus detection. No specific vaccine is available for the virus although monoclonal antibody treatment has been seen to be effective along with favipiravir. The high mortality and complications caused by the virus underscores the necessity to develop alternative modes of vaccination. One such method has been designed in this study using peptide cocktail consisting of the immunologically important epitopes for use as vaccine. The human leucocytic antigens that are used for the study were analyzed for their presence in various ethnic Indian populations. This study may serve as a new avenue for development of more efficient peptide cocktail vaccines in recent future based on the population genetics and ethnicity.

Indexed as

Nipah VirusEpidemiologic StudiesEpitopesHumansPeptidesVaccines, SubunitEpitopesPeptidesVaccines, SubunitEpitope predictionHLA distribution in Indian populationNipah virusPeptide cocktail vaccinePopulation coverage

Identifiers

PMID37955744

DOI10.1093/nar/gky357

OpenAlexW4388631071

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.