Evidence map›Paper›PMID 37955284›Full record

Observational studyAnnals of clinical and translational neurology2024

Short-chain fatty acid producers in the gut are associated with pediatric multiple sclerosis onset.

Vinicius A Schoeps, Xiaoyuan Zhou, Mary K Horton, Feng Zhu, Kathryn E McCauley, Zahra Nasr, Akash Virupakshaiah, Mark P Gorman, Leslie A Benson, Bianca Weinstock-Guttman and 15 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Female-enrichedbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Vinicius A Schoeps *Department of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-8875-0567
Xiaoyuan Zhou *Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Mary K HortonDivision of Epidemiology, University of California, Berkeley, Berkeley, California, USA.
Feng ZhuDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Kathryn E McCauleyDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Zahra NasrDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-6172-1432
Akash VirupakshaiahDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0003-2624-9974
Mark P GormanDepartment of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.
Leslie A BensonDepartment of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA.
Bianca Weinstock-GuttmanDepartment of Neurology, State University of New York, Buffalo, New York, USA.
Amy WaldmanDepartment of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Brenda L BanwellDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Amit Bar-OrDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ruth Ann MarrieDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Gary van DomselaarDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Julia O'MahonyDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Ali I MirzaDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Charles N BernsteinDepartment of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
E Ann YehThe Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
T Charles CasperDepartment of Pediatrics, The University of Utah, Salt Lake City, Utah, USA.
Susan V LynchDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Helen TremlettDivision of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.
Sergio BaranziniDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.
Emmanuelle WaubantDepartment of Neurology, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-5188-0157
US Network of Pediatric MS Centers

Funding

Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
Childhood stress and multiple sclerosis: implications on risk and clinical outcomesF31NS108668 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HORTON, MARY · 2018 to 2020
$121k
NINDS NIH HHS F13NS108668NINDS NIH HHS F31 NS108668NINDS NIH HHS R01 NS071463NINDS NIH HHS R01NS071463
6 · The paper itself

Abstract

objectiveThe relationship between multiple sclerosis and the gut microbiome has been supported by animal models in which commensal microbes are required for the development of experimental autoimmune encephalomyelitis. However, observational study findings in humans have only occasionally converged when comparing multiple sclerosis cases and controls which may in part reflect confounding by comorbidities and disease duration. The study of microbiome in pediatric-onset multiple sclerosis offers unique opportunities as it is closer to biological disease onset and minimizes confounding by comorbidities and environmental exposures.

methodsA multicenter case-control study in which 35 pediatric-onset multiple sclerosis cases were 1:1 matched to healthy controls on age, sex, self-reported race, ethnicity, and recruiting site. Linear mixed effects models, weighted correlation network analyses, and PICRUSt2 were used to identify microbial co-occurrence networks and for predicting functional abundances based on marker gene sequences.

resultsTwo microbial co-occurrence networks (one reaching significance after adjustment for multiple comparisons; q < 0.2) were identified, suggesting interdependent bacterial taxa that exhibited association with disease status. Both networks indicated a potentially protective effect of higher relative abundance of bacteria observed in these clusters. Functional predictions from the significant network suggested a contribution of short-chain fatty acid producers through anaerobic fermentation pathways in healthy controls. Consistent family-level findings from an independent Canadian-US study (19 case/control pairs) included Ruminococaccaeae and Lachnospiraceae (p < 0.05). Macronutrient intake was not significantly different between cases and controls, minimizing the potential for dietary confounding.

interpretationOur results suggest that short-chain fatty acid producers may be important contributors to multiple sclerosis onset.

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsCanadaCase-Control StudiesChildFatty Acids, VolatileHumansFatty Acids, Volatile

Identifiers

PMID37955284
PMCPMC10791026

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.