Evidence map›Paper›PMID 37955219›Full record

ArticleThe Indian journal of medical research2023

Evaluation of cell adhesion molecules (LFA-1 and L-selectin) in ankylosing spondylitis patients after treatment with β-D-mannuronic acid (M2000).

Mohammad Javad Fattahi, Bernd H A Rehm, Hidenori Matsuo, Salvatore Cuzzocrea, Fahimeh Jafarnezhad-Ansariha, Hossein Ahmadi, Farzaneh Tofighi-Zavareh, Mona Oraei, Zahra Aghazadeh, Abbas Mirshafiey

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In one paragraph

Article in The Indian journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 68% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Mohammad Javad FattahiDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran; Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Bernd H A RehmInstitute of Fundamental Sciences, Massey University, Palmerston North, New Zealand.
Hidenori MatsuoDepartment of Clinical Research, Nagasaki Kawatana Medical Center, Nagasaki, Japan.
Salvatore CuzzocreaDepartment of Chemical, Biological, Pharmaceutical & Environmental Sciences, University of Messina, Messina, Italy.
Fahimeh Jafarnezhad-AnsarihaDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran; Department of Immunology, International Campus, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein AhmadiDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Farzaneh Tofighi-ZavarehDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mona OraeiDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Zahra AghazadehDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Abbas MirshafieyDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Children's Medical Center · IRShiraz University of Medical Sciences · IRTehran University of Medical Sciences · IRUniversity of Messina · ITNagasaki Kawatana Medical Center · JPShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & objectives: To examine β-D-mannuronic acid (M2000) effects on L-selectin shedding and leucocyte function-associated antigen-1 (LFA-1) expression as mechanisms of action of this drug in patients with ankylosing spondylitis (AS). Methods: To investigate the molecular consequences of β-D-mannuronic acid on L-selectin shedding, flow cytometry method was used. Furthermore, the effect of it on LFA-1 gene expression was analyzed by using quantitative real time (qRT)-PCR technique. Results: The LFA-1 expression in patients with AS was higher than controls (P=0.046). The LFA-1 expression after 12 wk therapy with β-D-mannuronic acid was meaningfully decreased (P=0.01). After 12 wk treatment with β-D-mannuronic acid, the frequency of CD62L-expressing CD4+ T cells in patients with AS, was not considerably altered, compared to the patients before therapy (P=0.5). Furthermore, after 12 wk therapy with β-D-mannuronic acid, L-selectin expression levels on CD4+ T-cells in patients with AS, were not remarkably changed, compared to the expression levels of these in patients before treatment (P=0.2). Interpretation & conclusions: The results of this study for the first time showed that β-D-mannuronic acid can affect events of adhesion cascade in patients with AS. Moreover, β-D-mannuronic acid presented as an acceptable benefit to AS patients and could aid in the process of disease management.

Indexed as

Spondylitis, AnkylosingCell Adhesion MoleculesHexuronic AcidsHumansL-SelectinLymphocyte Function-Associated Antigen-1Cell Adhesion MoleculesHexuronic AcidsL-SelectinLymphocyte Function-Associated Antigen-1mannuronic acidAnkylosing spondylitisleucocyte function-associated antigen-1L-selectinM2000nonsteroidal anti-inflammatory drugsβ-D-mannuronic acid

Identifiers

PMID37955219
PMCPMC10443726
OpenAlexW4388535758

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.