SynthesisFrontiers in human neuroscience2023
Altered brain functional networks in schizophrenia with persistent negative symptoms: an activation likelihood estimation meta-analysis.
Synthesis in Frontiers in human neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed.
- Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Data-driven schizophrenia subtyping via brain atrophy trajectories and functional connectivity.Translational psychiatry · 2026Article
- Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI.Journal of pain research · 2026Review
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- Insular Cortex-Biology and Its Role in Psychiatric Disorders: A Narrative Review.Brain sciences · 2025Review
- The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health.Biology · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate brain structural and functional characteristics of three brain functional networks including default mode network (DMN), central executive network (CEN), and salience network (SN) in persistent negative symptoms (PNS) patients. Methods: We performed an activation likelihood estimation (ALE) meta-analysis of functional connectivity (FC) studies and voxel-based morphometry (VBM) studies to detect specific structural and functional alterations of brain networks between PNS patients and healthy controls. Results: Seventeen VBM studies and twenty FC studies were included. In the DMN, PNS patients showed decreased gray matter in the bilateral medial frontal gyrus and left anterior cingulate gyrus and a significant reduction of FC in the right precuneus. Also, PNS patients had a decrease of gray matter in the left inferior parietal lobules and medial frontal gyrus, and a significant reduction of FC in the bilateral superior frontal gyrus in the CEN. In comparison with healthy controls, PNS patients exhibited reduced gray matter in the bilateral insula, anterior cingulate gyrus, left precentral gyrus and right claustrum and lower FC in these brain areas in the SN, including the left insula, claustrum, inferior frontal gyrus and extra-nuclear. Conclusion: This meta-analysis reveals brain structural and functional imaging alterations in the three networks and the interaction among these networks in PNS patients, which provides neuroscientific evidence for more personalized treatment.Systematic Review RegistrationThe PROSPERO (https://www.crd.york.ac.uk/PROSPERO/, registration number: CRD42022335962).
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