Evidence map›Paper›PMID 37954896›Full record

ArticleRegenerative biomaterials2023

Development of photoreactive demineralized bone matrix 3D printing colloidal inks for bone tissue engineering.

Katie J Hogan, Hayriye Öztatlı, Marissa R Perez, Sophia Si, Reyhan Umurhan, Elysa Jui, Ziwen Wang, Emily Y Jiang, Sa R Han, Mani Diba and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
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  4. Review
  5. [Research progress in three-dimensional-printed bone scaffolds combined with vascularized tissue flaps for segmental bone defect reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  6. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Katie J HoganDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Hayriye ÖztatlıDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Marissa R PerezDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Sophia SiDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Reyhan UmurhanDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Elysa JuiDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Ziwen WangDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Emily Y JiangDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Sa R HanDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Mani DibaDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
K Jane Grande-AllenDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Bora GaripcanInstitute of Biomedical Engineering, Boğaziçi University, İstanbul, 34684, Turkey.
Antonios G MikosDepartment of Bioengineering, Rice University, MS-142, 6500 Main Street, Houston, TX 77030, USA.
Rice University · USBaylor College of Medicine · USBoğaziçi University · TR

Funding

Training and Dissemination CoreP41EB023833 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI FISHER, JOHN P · 2017 to 2021
$6.2M
NIBIB NIH HHS P41 EB023833
6 · The paper itself

Abstract

Demineralized bone matrix (DBM) has been widely used clinically for dental, craniofacial and skeletal bone repair, as an osteoinductive and osteoconductive material. 3D printing (3DP) enables the creation of bone tissue engineering scaffolds with complex geometries and porosity. Photoreactive methacryloylated gelatin nanoparticles (GNP-MAs) 3DP inks have been developed, which display gel-like behavior for high print fidelity and are capable of post-printing photocrosslinking for control of scaffold swelling and degradation. Here, novel DBM nanoparticles (DBM-NPs, ∼400 nm) were fabricated and characterized prior to incorporation in 3DP inks. The objectives of this study were to determine how these DBM-NPs would influence the printability of composite colloidal 3DP inks, assess the impact of ultraviolet (UV) crosslinking on 3DP scaffold swelling and degradation and evaluate the osteogenic potential of DBM-NP-containing composite colloidal scaffolds. The addition of methacryloylated DBM-NPs (DBM-NP-MAs) to composite colloidal inks (100:0, 95:5 and 75:25 GNP-MA:DBM-NP-MA) did not significantly impact the rheological properties associated with printability, such as viscosity and shear recovery or photocrosslinking. UV crosslinking with a UV dosage of 3 J/cm

Indexed as

3D printingbone tissue engineeringcolloidal hydrogelsdemineralized bone matrix

Identifiers

PMID37954896
PMCPMC10634525
OpenAlexW4387772259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.