Evidence map›Paper›PMID 37954510›Full record

ArticleJACC. Advances2023

Association of Atrial Fibrillation With Stroke and Dementia Accounting for Left Atrial Function and Size.

Michael J Zhang, Yuekai Ji, Wendy Wang, Faye L Norby, Romil Parikh, Anne A Eaton, Riccardo M Inciardi, Alvaro Alonso, Elsayed Z Soliman, Thomas H Mosley and 5 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 2 countries.

Michael J ZhangCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.
Yuekai JiDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Wendy WangDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Faye L NorbyDepartment of Cardiology, Center for Cardiac Arrest Prevention, Cedars-Sinai Smidt Heart Institute, Los Angeles, California.
Romil ParikhDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Anne A EatonDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
Riccardo M InciardiDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, Institute of Cardiology, University of Brescia, Brescia, Italy.
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Elsayed Z SolimanCardiovascular Medicine Section, Department of Internal Medicine, Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina.
Thomas H MosleyDivision of Geriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Michelle C JohansenDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, NIH, Bethesda, Maryland.
Amil M ShahCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Scott D SolomonCardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Lin Yee ChenCardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.
University of Minnesota · USBrigham and Women's Hospital · USCedars-Sinai Smidt Heart Institute · USEmory University · USJohns Hopkins University · USNational Institute of Neurological Disorders and Stroke · USUniversity of Brescia · ITUniversity of Mississippi Medical Center · USWake Forest University · US

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Jonathan David Glass · 2020 to 2026
$29.0M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Mapping the Progression to HFpEF in the Elderly through Longitudinal Changes in Cardiac FunctionR01HL135008 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Amil M Shah · 2017 to 2026
$11.5M
Cardiovascular Disease Epidemiology &Prevention TrngT32HL007779 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI PAMELA L. Lutsey, JAMES S PANKOW · 1994 to 2026
$9.3M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5M
The ARIC and Neurocognitive Longitudinal StudyR01HL070825 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI MOSLEY, THOMAS H · 2002 to 2004
$5.1M
Cognitive Aging, Brain Morphology, and Arrhythmias in Hispanics/Latinos: Implications for Prevention and Management of Alzheimer's Disease-Related DementiasRF1NS127266 · NINDS · UNIVERSITY OF MINNESOTA · PI CHEN, LIN YEE, GONZALEZ, HECTOR M · 2022 to 2022
$4.1M
Early Detection of Transthyretin Cardiac Amyloidosis: Defining a Novel Target for HFpEF Treatment and Prevention in Late LifeR01HL150342 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA, SHAH, AMIL M · 2020 to 2023
$4.1M
Novel application of Digital signals of movement, sleep and heart rhythms for detection of Alzheimer's Disease and Related DementiasR01AG075883 · NIA · JOHNS HOPKINS UNIVERSITY · PI Lin Yee Chen, Ciprian M Crainiceanu · 2022 to 2026
$3.8M
NHLBI NIH HHS F32 HL152523NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS K01 HL164764NHLBI NIH HHS K24 HL148521NHLBI NIH HHS K24 HL152008NHLBI NIH HHS K24 HL155813NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL126637NHLBI NIH HHS R01 HL135008NHLBI NIH HHS R01 HL137338NHLBI NIH HHS R01 HL141288NHLBI NIH HHS R01 HL143224NHLBI NIH HHS R01 HL148218NHLBI NIH HHS R01 HL150342NHLBI NIH HHS R01 HL158022NHLBI NIH HHS R01 HL160025NHLBI NIH HHS T32 HL007779NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG075883NINDS NIH HHS K23 NS112459NINDS NIH HHS RF1 NS127266
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is associated with higher risks of ischemic stroke (IS) and dementia. Whether alterations in left atrial (LA) function or size-atrial myopathy-confound these associations remains unknown.

objectivesThe purpose of this study was to examine the association of prevalent and incident AF with ischemic stroke and dementia in the ARIC (Atherosclerosis Risk In Communities) study, adjusting for LA function and size.

methodsParticipants at visit 5 (2011-2013) with echocardiographic LA function (reservoir, conduit, contractile strain, and emptying fraction) and size (maximal, minimal volume index) data, and without prevalent stroke or dementia were followed through 2019. For analysis, we used time-varying Cox regression.

resultsAmong 5,458 participants (1,193 with AF, mean age of 76 years) in the stroke analysis and 5,461 participants (1,205 with AF, mean age of 75 years) in the dementia analysis, 209 participants developed ischemic stroke, and 773 developed dementia over 7.1 years (median). In a demographic and risk factor-adjusted model, AF was significantly associated with ischemic stroke (HR, 1.63; 95% CI: 1.11-2.37) and dementia (HR: 1.38, 95% CI: 1.13-1.70). After additionally adjusting for LA reservoir strain, these associations were attenuated and no longer statistically significant (stroke [HR: 1.33, 95% CI: 0.88-2.00], dementia [HR: 1.15, 95% CI: 0.92-1.43]). Associations with ischemic stroke and dementia were also attenuated and not statistically significant after adjustment for LA contractile strain, emptying fraction, and minimal volume index.

conclusionsAF-ischemic stroke and AF-dementia associations were not statistically significant after adjusting for measures of atrial myopathy. This proof-of-concept analysis does not support AF as an independent risk factor for ischemic stroke and dementia.

Indexed as

atrial myopathyleft atriumreservoir strainspeckle tracking

Identifiers

PMID37954510
PMCPMC10634508
OpenAlexW4385335821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.