Evidence map›Paper›PMID 37954502›Full record

ArticleFunction (Oxford, England)2022

Valerie Politis-Barber, Heather L Petrick, Arthe Raajendiran, Genevieve J DesOrmeaux, Henver S Brunetta, Larissa M Dos Reis, Marcelo A Mori, David C Wright, Matthew J Watt, Graham P Holloway

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Oxidative Phosphorylation in Uncoupled Mitochondria.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Valerie Politis-BarberDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
Heather L PetrickDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
Arthe RaajendiranDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
Genevieve J DesOrmeauxDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
Henver S BrunettaDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
Larissa M Dos ReisDepartment of Genetics, Evolution, Microbiology and Immunology, University of Campinas, Campinas - SP 13083-970, Brazil.
Marcelo A MoriDepartment of Biochemistry and Tissue Biology, University of Campinas, Campinas - SP 13083-970, Brazil.
David C WrightDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
Matthew J WattDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
Graham P HollowayDepartment of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd E, Guelph, ON N1G 2W1, Canada.
University of Guelph · CAUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within brown adipose tissue (BAT), the brain isoform of creatine kinase (CKB) has been proposed to regulate the regeneration of ADP and phosphocreatine in a futile creatine cycle (FCC) that stimulates energy expenditure. However, the presence of FCC, and the specific creatine kinase isoforms regulating this theoretical model within white adipose tissue (WAT), remains to be fully elucidated. In the present study, creatine did not stimulate respiration in cultured adipocytes, isolated mitochondria or mouse permeabilized WAT. Additionally, while creatine kinase ubiquitous-type, mitochondrial (CKMT1) mRNA and protein were detected in human WAT, shRNA-mediated reductions in

Indexed as

Adipose Tissue, BeigeCreatineAdipose Tissue, WhiteAnimalsCreatine KinaseEnergy MetabolismHumansMiceMitochondriaCKMT1A protein, humanCreatineCreatine Kinaseadipose tissuebeigingbrowningcreatinecreatine kinaseenergy expenditurefutile cyclingmetabolismmitochondriamitochondrial bioenergetics

Identifiers

PMID37954502
PMCPMC10633789
OpenAlexW4285795729

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.