Evidence map›Paper›PMID 37954429›Full record

ArticleFrontiers in pediatrics2023

SARS-CoV-2 seroprevalence in French 9-year-old children and their parents after the first lockdown in 2020.

Marie Aline Charles, Pierre-Yves Ancel, Thierry Simeon, Laetitia Marchand-Martin, Cécile Zaros, Marie-Noelle Dufourg, Valérie Benhamou, Hélène Blanché, Jean-François Deleuze, Delphine Rahib and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04392388 (Health, Perception, Practices, Relations and Social Inequalities in the General Population During the Covid-19 Crisis - Serology), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04392388 completednot on this map

Health, Perception, Practices, Relations and Social Inequalities in the General Population During the Covid-19 Crisis - Serology

TypeobservationalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2020 to 2023Enrolled96,883ConditionsSARS-CoV 2ArmsNon applicable
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marie Aline CharlesUMS Elfe, Ined, Inserm, EFS, Aubervilliers, France.
Pierre-Yves AncelCenter for Research in Epidemiology and Statistics, Paris Cité University, INSERM, INRAE, Paris, France.
Thierry SimeonUMS Elfe, Ined, Inserm, EFS, Aubervilliers, France.
Laetitia Marchand-MartinCenter for Research in Epidemiology and Statistics, Paris Cité University, INSERM, INRAE, Paris, France.
Cécile ZarosUMS Elfe, Ined, Inserm, EFS, Aubervilliers, France.
Marie-Noelle DufourgUMS Elfe, Ined, Inserm, EFS, Aubervilliers, France.
Valérie BenhamouCenter for Research in Epidemiology and Statistics, Paris Cité University, INSERM, INRAE, Paris, France.
Hélène BlanchéFondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, CEPH-Biobank, Paris, France.
Jean-François DeleuzeFondation Jean Dausset-Centre d'Etude du Polymorphisme Humain, CEPH-Biobank, Paris, France.
Delphine RahibHealth Prevention and Promotion Department, Santé Publique France, Saint-Maurice, France.
Nathalie LydieHealth Prevention and Promotion Department, Santé Publique France, Saint-Maurice, France.
Xavier de LamballerieUnité des Virus Emergents, Aix Marseille University, IRD, INSERM, IHU Méditerranée Infection, Marseille, France.
Fabrice CarratInstitut Pierre-Louis d'Epidémiologie et de Santé Publique, Sorbonne Université, Inserm, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Children have been significantly less affected by COVID-19 than adults and presented with milder and less symptomatic forms of the disease. However, there has been suggestion that children older than 10 years and adolescents exhibits features closer to that of young adults. Most studies combine children in different age-groups and lack sufficient numbers to explore in detail age specificities. We report data on a population-based sample of 2,555 children at the pivotal age of 9 years. Methods: In April 2020, the participants in two French nationwide cohorts of children, Elfe and Epipage2, were invited to take part into an online survey about Covid related symptoms and family life during the lockdown. A second questionnaire was sent on May 5. This questionnaire also proposed to the child included in the cohort and to one of his/her parents to take part into a capillary blood collection for Covid serology. Families who agreed to the serological survey were sent kits for dried blood spots self-sampling (DBS) with instructions. Samples were processed with a commercial Elisa test (Euroimmun®, Lübeck, Germany) to detect anti-SARS-CoV-2 antibodies (IgG) directed against the S1 domain of the spike protein of the virus. Results: Children's acceptance rate for the serological survey was around 60%. 2,555 serological results were analyzed. The weighted prevalence of a positive Elisa Spike serology was 2.8% in 9 yr-old children (95% CI: 1.7%-4.0%). Positive serology was found in 8.6% (7.4%-9.7%) of parents who provided blood. There was a significant association ( Discussion: We have shown that 9-yr old children had a lower susceptibility to SARS-Cov2 infection than adults with the initial Chinese strain, similar to younger children and estimated that around 3% of them have developed antibodies against SARS-Cov2 in France after the first wave of the Covid-19 epidemics.

Indexed as

childrenCOVID-19Francehouseholdserology

Identifiers

PMID37954429
PMCPMC10634499

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.