Evidence map›Paper›PMID 37954145›Full record

ArticleComputational and structural biotechnology journal2023

Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression.

Munishikha Kalia, Mattia Miotto, Deborah Ness, Sarah Opie-Martin, Thomas P Spargo, Lorenzo Di Rienzo, Tommaso Biagini, Francesco Petrizzelli, Ahmad Al Khleifat, Renata Kabiljo and 8 more

Open access · goldAbstract read
In one paragraph

Article in Computational and structural biotechnology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  10. Osmolyte-induced protein stability changes explained by graph theory.Computational and structural biotechnology journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Munishikha KaliaDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
Mattia MiottoCenter for Life Nano & Neuro Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy.
Deborah NessDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
Sarah Opie-MartinDepartment of Basic and Clinical Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Thomas P SpargoDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
Lorenzo Di RienzoCenter for Life Nano & Neuro Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy.
Tommaso BiaginiBioinformatics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
Francesco PetrizzelliBioinformatics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
Ahmad Al KhleifatDepartment of Basic and Clinical Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Renata KabiljoDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
Project MinE ALS Sequencing Consortium
SOD1-ALS clinical and genetic data collection group
Tommaso MazzaBioinformatics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
Giancarlo RuoccoCenter for Life Nano & Neuro Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy.
Edoardo MilanettiCenter for Life Nano & Neuro Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy.
Richard Jb DobsonDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
Ammar Al-ChalabiDepartment of Basic and Clinical Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK.
Alfredo IacoangeliDepartment of Biostatistics and Health Informatics, King's College London, London, UK.
King's College London · GBItalian Institute of Technology · ITCasa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the superoxide dismutase 1 (

Indexed as

Amyotrophic lateral sclerosisDiseaseassociated SOD1 mutationsMolecular dynamics (MD) simulationsPerformed principal component analysisSuperoxide Dismutase type 1 (SOD1)Survival analysis

Identifiers

PMID37954145
PMCPMC10637862
OpenAlexW4386813236

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.