Evidence map›Paper›PMID 37953784›Full record

ArticlePeerJ2023

Association of triglyceride-glucose index with the risk of prostate cancer: a retrospective study.

Tianqi Li, Yijie Zhou, Jinru Wang, Songtao Xiao, Yajun Duan, Caihong Li, Yi Gao, Hengqing An, Ning Tao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tianqi Li *School of Public Health, Xinjiang Medical University, Urumqi, China.
Yijie Zhou *School of Public Health, Xinjiang Medical University, Urumqi, China.
Jinru WangSchool of Public Health, Xinjiang Medical University, Urumqi, China.
Songtao XiaoSchool of Public Health, Xinjiang Medical University, Urumqi, China.
Yajun DuanSchool of Public Health, Xinjiang Medical University, Urumqi, China.
Caihong LiSchool of Public Health, Xinjiang Medical University, Urumqi, China.
Yi GaoSchool of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.
Hengqing AnDepartment of Urology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Ning TaoDepartment of Epidemiological Statistics, School of Public Health, Xinjiang Medical University, Urumqi, China.
Xinjiang Medical University · CNFirst Affiliated Hospital of Xinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prostate cancer is the most common malignancy in men, and its incidence is increasing year by year. Some studies have shown that risk factors for prostate cancer are related to insulin resistance. The triglyceride-glucose (TyG) index is a marker of insulin resistance. We investigated the validity of TyG index for predicting prostate cancer and the dose-response relationship in prostate cancer in relation to it. Objective: To investigate the risk factors of TyG index and prostate cancer prevalence. Methods: This study was screened from the First Affiliated Hospital of Xinjiang Medical University and included 767 people, including 136 prostate cancer patients in the case group and 631 healthy people in the control group. The relationship between TyG index and the risk of prostate cancer was analyzed by one-way logistic regression, adjusted for relevant factors, and multi-factor logistic regression analysis was performed to further investigate the risk factors affecting the prevalence of prostate cancer. ROC curves and Restricted Cubic Spline were established to determine the predictive value and dose-response relationship of TyG index in prostate cancer. Results: Blood potassium (OR = 0.056, 95% CI [0.021-0.148]), total cholesterol (OR = 1.07, 95% CI [0.792-1.444]) and education level (OR = 0.842, 95% CI [0.418-1.697]) were protective factors for prostate cancer, alkaline phosphatase, age, LDL, increased the risk of prostate cancer (OR = 1.016, 95% CI [1.006-1.026]) (OR = 139.253, 95% CI [18.523-1,046.893] (OR = 0.318, 95% CI [0.169-0.596]); TyG index also was a risk factor for prostate cancer, the risk increased with TyG levels,and persons in the TyGQ3 group (8.373-8.854 mg/dL) was 6.918 times (95% CI [2.275-21.043]) higher than in the Q1 group,in the TyGQ4 group (≥8.854) was 28.867 times of those in the Q1 group (95% CI [9.499-87.727]). Conclusion: TyG index may be a more accurate and efficient predictor of prostate cancer.

Indexed as

Insulin ResistanceProstatic NeoplasmsAlkaline PhosphataseGlucoseHumansMaleRetrospective StudiesAlkaline PhosphataseGlucoseHyperinsulinemiaInsulin resistanceLow-density lipoproteinProstate cancerTotal cholesterolTriglyceride-glucose (TyG) index

Identifiers

PMID37953784
PMCPMC10637243
OpenAlexW4388462225

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.