Evidence map›Paper›PMID 37953496›Full record

ArticleFEBS open bio2024

Acquired and intrinsic resistance to vemurafenib in BRAF

Ping Zhang, Laura Esmee Kuil, Levi Conrad Maria Buil, Stephan Freriks, Jos Hendrik Beijnen, Olaf van Tellingen, Mark Cornelis de Gooijer

Open access · goldAbstract read
In one paragraph

Article in FEBS open bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Molecular Underpinnings of Brain Metastases.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Ping ZhangDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Laura Esmee KuilDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0003-3330-1371
Levi Conrad Maria BuilDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Stephan FreriksDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jos Hendrik BeijnenDepartment of Pharmacy and Pharmacology, The Netherlands Cancer Institute/MC Slotervaart Hospital, Amsterdam, The Netherlands.ORCID 0000-0003-0118-561X
Olaf van TellingenDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-1037-6269
Mark Cornelis de GooijerDivision of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-2812-991X
The Netherlands Cancer Institute · NLDutch Cancer Society · NLManchester Academic Health Science Centre · GBShandong University · CNUtrecht University · NL

Funding

Stichting STOPhersentumoren.nl
6 · The paper itself

Abstract

BRAF

Indexed as

Brain NeoplasmsMelanomaAnimalsATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2HumansIndolesMiceNeoplasm ProteinsProto-Oncogene Proteins B-rafSulfonamidesVemurafenibATP-Binding Cassette TransportersATP Binding Cassette Transporter, Subfamily G, Member 2BRAF protein, humanIndolesNeoplasm ProteinsProto-Oncogene Proteins B-rafSulfonamidesVemurafenibblood-brain barrierBRAFbrain metastasesmelanomaresistancevemurafenib

Identifiers

PMID37953496
PMCPMC10761933
OpenAlexW4388636910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.