Reversible Reactions of Nitric Oxide with a Binuclear Iron(III) Nitrophorin Mimic.

Vinay K Sharma, Azad Saini, Natalia Fridman, Harry B Gray, Zeev Gross

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vinay K SharmaSchulich Faculty of Chemistry, Technion - Israel Institute of Technology Institution, Haifa, 32000, Israel.

Azad SainiSchulich Faculty of Chemistry, Technion - Israel Institute of Technology Institution, Haifa, 32000, Israel.

Natalia FridmanSchulich Faculty of Chemistry, Technion - Israel Institute of Technology Institution, Haifa, 32000, Israel.

Harry B GrayBeckman Institute, California Institute of Technology, Pasadena, California, 91125, USA.

Zeev GrossSchulich Faculty of Chemistry, Technion - Israel Institute of Technology Institution, Haifa, 32000, Israel.ORCID https://orcid.org/0000-0003-1170-2115

Funding

ELECTRON-TRANSFER PROCESSES IN IRON AND COPPER PROTEINSR01DK019038 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRAY, HARRY B, WINKLER, JAY R · 1986 to 2023

$7.0M

NIDDK NIH HHS R01 DK019038NIDDK NIH HHS R01DK019038

6 · The paper itself

Abstract

Construction of functional synthetic systems that can reversibly bind and transport the most biologically important gaseous molecules, oxygen and nitric oxide (NO), remains a contemporary challenge. Myoglobin and nitrophorin perform these respective tasks employing a protein-embedded heme center where one axial iron site is occupied by a histidine residue and the other is available for small molecule ligation, structural features that are extremely difficult to mimic in protein-free environments. Indeed, the hitherto reported designs rely on sophisticated multistep syntheses for limiting access to one of the two axial coordination sites in small molecules. We have shown previously that binuclear Ga(III) and Al(III) corroles have available axial sites, and now report a redox-active binuclear Fe(III) corrole, (1-Fe)

Indexed as

corroledimerhemenitric oxidereversible reaction

Identifiers

PMID37953366

DOI10.1002/chem.202302860

PMCPMC11410176

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.