ArticleJournal of endocrinological investigation2024
Does gestational diabetes mellitus increase the risk of cardiovascular disease? A Mendelian randomization study.
Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Vitamin D status during pregnancy modulates the effect of pre-pregnancy obesity on gestational diabetes mellitus risk: a birth cohort study.Public health nutrition · 2026Article
- Stress-induced hyperglycemia ratio and gestational diabetes mellitus: a cross-sectional study based on NHANES database.Therapeutic advances in endocrinology and metabolism · 2026Article
- Associations of gestational diabetes mellitus with the risk of cardiometabolic diseases: results from NHANES and mendelian randomization analyses.Diabetology & metabolic syndrome · 2025Article
- Factors influencing dietary compliance among patients with gestational diabetes mellitus: a retrospective analysis.American journal of translational research · 2025Article
- Fasting or 2-hour postprandial plasma glycemic criteria for gestational diabetes mellitus are aassociated with distinct adverse outcomes.BMC pregnancy and childbirth · 2024Article
- Association of VDR gene variant rs2228570-Heliyon · 2024Article
- Association between gestational diabetes and cardiovascular disease within 24 months postpartum.American journal of obstetrics & gynecology MFM · 2024Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purposeIn recent years, epidemiological studies have revealed the relationship between gestational diabetes mellitus (GDM) and cardiovascular disease (CVD). In this study, we utilized Mendelian randomization (MR) to investigate the potential causal impact of GDM on cardiovascular disease for the first time.
methodsWe retrieved summary statistics from published genome-wide association studies. MR was first performed using significant SNPs extracted from the eighth data release of the FinnGen study. Next, a replication analysis for coronary artery disease (CAD) was conducted in another European ancestry population to validate our findings. Finally, mediation analysis was carried out to assess potential mediation effects.
resultsOur data analysis revealed that genetically predicted GDM was significantly associated with increased CAD risk (OR 1.10, 95% CI 1.02-1.18, p 0.006). Replication analysis confirmed a significant genetic association between GDM and CAD (OR 1.07, 95% CI 1.02-1.12, p 0.003) in another European ancestry population. Mediation analysis indicated no significant mediation effect by type 2 diabetes mellitus (T2DM) on the GDM-CAD relationship (mediation effect β [95% CI]: 0.005 [-0.003, -0.017]).
conclusionWomen with a prior history of GDM face an elevated risk of future CAD. This increased risk of CAD cannot be solely attributed to the subsequent onset of diabetes. Regular CAD risk assessment and primary prevention strategies are of paramount importance for women with a history of GDM.
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