Evidence map›Paper›PMID 37952216›Full record

ArticleClinical and experimental immunology2024

The CXCL10-CXCR3 axis plays an important role in Kawasaki disease.

Sho Hosaka, Kazuo Imagawa, Yusuke Yano, Lisheng Lin, Junko Shiono, Miho Takahashi-Igari, Hideki Hara, Daisuke Hayashi, Hironori Imai, Atsushi Morita and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sho HosakaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.ORCID 0000-0002-2792-1235
Kazuo ImagawaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
Yusuke YanoDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
Lisheng LinDepartment of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba City, Japan.
Junko ShionoDepartment of Pediatric Cardiology, Ibaraki Children's Hospital, Mito City, Japan.
Miho Takahashi-IgariDepartment of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
Hideki HaraDepartment of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
Daisuke HayashiDepartment of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
Hironori ImaiDepartment of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba City, Japan.
Atsushi MoritaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
Hiroko FukushimaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.ORCID 0000-0002-1290-3501
Hidetoshi TakadaDepartment of Pediatrics, University of Tsukuba Hospital, Tsukuba City, Japan.
Tsukuba Medical Center Hospital · JPUniversity of Tsukuba · JPUniversity of Tsukuba Hospital · JPIbaraki Children's Hospital · JP

Funding

Kawasaki Disease Research
6 · The paper itself

Abstract

The precise pathogenesis of Kawasaki disease remains unknown. In an attempt to elucidate the pathogenesis of KD through the analysis of acquired immunity, we comprehensively examined the immunophenotypic changes in immune cells such as lymphocytes and monocytes along with various cytokines, focusing on differences between pre- and post- treatment samples. We found high levels of CXCL9 and CXCL10 chemokines that decreased with treatment, which coincided with a post-treatment expansion of Th1 cells expressing CXCR3. Our results show that the CXCL10-CXCR3 axis plays an important role in the pathogenesis of KD.

Indexed as

Mucocutaneous Lymph Node SyndromeChemokine CXCL10Chemokine CXCL9CytokinesHumansMonocytesReceptors, CXCR3Th1 CellsChemokine CXCL10Chemokine CXCL9CXCL10 protein, humanCXCR3 protein, humanCytokinesReceptors, CXCR3CXCL10CXCR3Kawasaki diseaseTh1

Identifiers

PMID37952216
PMCPMC10929692
OpenAlexW4388608380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.